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Monocyte Chemotactic Protein 2 (MCP2)/CCL8 (CCL8) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4382209

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies… More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Monocyte Chemotactic Protein 2 (MCP2)/CCL8, Monoclonal Antibody
Full Product Name
Monocyte Chemotactic Protein 2 (MCP2)/CCL8 Mouse Monoclonal Antibody [Clone CCL8/3683]
Product Gene Name
anti-CCL8 antibody
Product Synonym Names
HC14; MCP2; MCP-2; SCYA8; SCYA10
Clonality
Monoclonal
Isotype
Mouse/IgG2c, kappa
Clone Number
CCL8/3683
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (lot specific)
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
99
OMIM
602283
3D Structure
ModBase 3D Structure for P80075
Immunogen
Human recombinant MCP2/CCL8 protein fragment (around aa24-98) (exact sequence is proprietary)
Cellular Localization
Secreted
Positive Control
Human small intestine, spleen or adrenal gland tissue.
Hu-chromosome Location
17q12
Unigene
271387
Applications Tested/Suitable for anti-CCL8 antibody
Immunohistochemistry-Formalin (IHC-F)
Application Notes for anti-CCL8 antibody
IHC (Formalin-fixed): 1-2ug/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH9.0, for 45 minutes at 95 degree C followed by cooling at RT for 20 minutes)

SDS-Page of anti-CCL8 antibody

SDS-PAGE Analysis Purified MCP2/CCL8 Mouse Monoclonal Antibody (CCL8/3683). Confirmation of Purity and Integrity of Antibody.
Mouse Anti-CCL8 Monoclonal Antibody – Cat# MBS4382209

Immunohistochemistry (IHC) of anti-CCL8 antibody

Mouse Anti-CCL8 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4382209

Other Notes

Small volumes of anti-CCL8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL8 purchase

MBS4382209 is an antibody targeting CCL8. Also known as Monocyte Chemotactic Protein 2 (MCP2)/CCL8 Mouse Monoclonal Antibody [Clone CCL8/3683]. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL8. It may not necessarily be applicable to this product.

NCBI GI #
2506280
NCBI GeneID
6355
NCBI Accession #
P80075.2
UniProt Primary Accession #
P80075
UniProt Secondary Accession #
P78388; A0AV77
UniProt Related Accession #
P80075
NCBI Official Full Name
C-C motif chemokine 8
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 8
NCBI Official Symbol
CCL8
NCBI Official Synonym Symbols
HC14; MCP2; MCP-2; SCYA8; SCYA10
UniProt Protein Name
C-C motif chemokine 8
UniProt Synonym Protein Names
HC14; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8MCP-2(6-76)
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL8
UniProt Synonym Gene Names
MCP2; SCYA10; SCYA8; MCP-2
UniProt Entry Name
CCL8_HUMAN
NCBI Protein Information
C-C motif chemokine 8; small-inducible cytokine A8; monocyte chemotactic protein 2; monocyte chemoattractant protein 2; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)

UniProt Comments for CCL8

CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: extracellular space

Molecular Function: heparin binding; chemokine activity; protein kinase activity; phospholipase activator activity

Biological Process: cellular calcium ion homeostasis; positive regulation of catalytic activity; exocytosis; cell-cell signaling; calcium ion transport; response to virus; immune response; chemotaxis; inflammatory response; signal transduction; protein amino acid phosphorylation
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Research Articles on CCL8

1. CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL8 antibody

 Reference Product  PubMed Publications
 CCR2 antibody  >48 publications with CCL8 and CCR2
 CCR5 antibody  >39 publications with CCL8 and CCR5
 CCR1 antibody  >24 publications with CCL8 and CCR1
 CCR3 antibody  >20 publications with CCL8 and CCR3
 CXCR3 antibody  >15 publications with CCL8 and CXCR3
 CXCR4 antibody  >13 publications with CCL8 and CXCR4
 CXCR2 antibody  >7 publications with CCL8 and CXCR2
 CCR8 antibody  >6 publications with CCL8 and CCR8

Pathways associated with anti-CCL8 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-CCL8 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >112 publications with CCL8 and Inflammation
 Necrosis Antibodies  >38 publications with CCL8 and Necrosis
 Lung Diseases Antibodies  >34 publications with CCL8 and Lung Diseases
 Hypersensitivity Antibodies  >26 publications with CCL8 and Hypersensitivity
 Disease Models, Animal Antibodies  >24 publications with CCL8 and Disease Models, Animal
 Respiratory Hypersensitivity Antibodies  >13 publications with CCL8 and Respiratory Hypersensitivity
 Atherosclerosis Antibodies  >9 publications with CCL8 and Atherosclerosis
 Lymphoma Antibodies  >8 publications with CCL8 and Lymphoma
 Lung Injury Antibodies  >7 publications with CCL8 and Lung Injury
 Arthritis, Rheumatoid Antibodies  >7 publications with CCL8 and Arthritis, Rheumatoid

Organs/Tissues associated with anti-CCL8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >170 publications with CCL8 and Blood
 Lung Antibodies  >37 publications with CCL8 and Lung
 Bone Antibodies  >27 publications with CCL8 and Bone
 Brain Antibodies  >13 publications with CCL8 and Brain
 Liver Antibodies  >12 publications with CCL8 and Liver
 Connective Tissue Antibodies  >11 publications with CCL8 and Connective Tissue
 Uterus Antibodies  >8 publications with CCL8 and Uterus
 Intestine Antibodies  >6 publications with CCL8 and Intestine
 Kidney Antibodies  >5 publications with CCL8 and Kidney
 Eye Antibodies  >5 publications with CCL8 and Eye
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