Mouse Anti-IGKC Monoclonal Antibody – Cat# MBS438322

Formalin-fixed, paraffin-embedded human Tonsil stained with Kappa Light Chain Monoclonal Antibody (SPM508).

Kappa Light Chain (IGKC) Antibody – Mouse Monoclonal

Name: IGKC Antibody; Monoclonal; Mouse; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS438322
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438322

MBS438322 is an antibody targeting IGKC. Also known as Kappa Light Chain (B-Cell Marker) Mouse Monoclonal Antibody. Reactive in Human.Does not react with Rat. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Kappa Light Chain (IGKC), Monoclonal Antibody

Full Product Name

Kappa Light Chain (B-Cell Marker) Mouse Monoclonal Antibody

Product Gene Name

anti-IGKC antibody

Product Synonym Names

HCAK1; Ig Kappa Chain C Region; IGKC; Immunoglobulin KM

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

SPM508

Host

Mouse

Species Reactivity

Human.
Does not react with Rat

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

~22.5kDa

3D Structure

ModBase 3D Structure for P01601

Cellular Localization

Cell Surface, Cytoplasmic and Secreted

Immunogen

Human B-Lymphoma Cells

Hu-Chromosome Location

2p11.2

Positive Control

293T, Raji or hPBL cells. Tonsil or Spleen

Applications Tested/Suitable for anti-IGKC antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

Application Notes for anti-IGKC antibody

Flow Cytometry (0.5-2.0ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-IGKC antibody

Takahashi H et. al. Pathol Res Prac 189:300-311 (1993).2. Momose H et. al. Hum Pathol. 23:1115-1119 (1992)

Other Notes

Small volumes of anti-IGKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGKC. It may not necessarily be applicable to this product.

NCBI GI #

857434459

NCBI GeneID

3514

NCBI Accession #

P01601.2

UniProt Primary Accession #

P01601

UniProt Secondary Accession #

A0A0B4J1Z3

UniProt Related Accession #

P01834; P04431; P01601

NCBI Official Full Name

Ig kappa chain V-ID region 16

NCBI Official Synonym Full Names

immunoglobulin kappa constant

NCBI Official Symbol

IGKC

NCBI Official Synonym Symbols

Km; HCAK1; IGKCD

UniProt Protein Name

Ig kappa chain V-ID region 16

UniProt Synonym Protein Names

Ig kappa chain V-I region HK101

UniProt Gene Name

IGKV1D-16

UniProt Entry Name

KV109_HUMAN

UniProt Comments for IGKC

KV109:

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: external side of plasma membrane; extracellular region; extracellular space; plasma membrane

Molecular Function: antigen binding; serine-type endopeptidase activity

Biological Process: B cell receptor signaling pathway; complement activation; complement activation, classical pathway; defense response to bacterium; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation; receptor-mediated endocytosis; regulation of immune response; retinal homeostasis

Disease: Immunoglobulin Kappa Light Chain Deficiency

Research Articles on IGKC

1. genetic polymorphism is associated with immunobiology of breast cancer in Japan

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IGKC antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
CD22 Mediated BCR Regulation Pathway antibodies	CD22 Mediated BCR Regulation Pathway Diagram
Classical Antibody-mediated Complement Activation Pathway antibodies	Classical Antibody-mediated Complement Activation Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
FCERI Mediated Ca+2 Mobilization Pathway antibodies	FCERI Mediated Ca+2 Mobilization Pathway Diagram
FCERI Mediated MAPK Activation Pathway antibodies	FCERI Mediated MAPK Activation Pathway Diagram
FCERI Mediated NF-kB Activation Pathway antibodies	FCERI Mediated NF-kB Activation Pathway Diagram

Organs/Tissues associated with anti-IGKC antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with IGKC and Blood
Lung Antibodies	>7 publications with IGKC and Lung
Vascular Antibodies	>3 publications with IGKC and Vascular
Muscle Antibodies	>2 publications with IGKC and Muscle
Eye Antibodies	>2 publications with IGKC and Eye
Uncharacterized Tissue Antibodies	>2 publications with IGKC and Uncharacterized Tissue
Skin Antibodies	>1 publications with IGKC and Skin
Intestine Antibodies	>1 publications with IGKC and Intestine