Mouse Anti-CD1A Monoclonal Antibody – Cat# MBS438445

Formalin-fixed, paraffin-embedded human Skin stained with CD1a Monoclonal Antibody (SPM120).

CD1A Antibody – Mouse Monoclonal

Name: CD1A Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS438445
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438445

MBS438445 is an antibody targeting CD1A. Also known as CD1a (Mature Langerhans Cells Marker) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD1a, Monoclonal Antibody

Full Product Name

CD1a (Mature Langerhans Cells Marker) Mouse Monoclonal Antibody

Product Gene Name

anti-CD1A antibody

Product Synonym Names

Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a antibody, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

SPM120

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

49kDa

OMIM

188370

3D Structure

ModBase 3D Structure for P06126

Cellular Localization

Cell Surface

Immunogen

Human thymus cells

Hu-Chromosome Location

1q23.1

Positive Control

MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.

Applications Tested/Suitable for anti-CD1A antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-CD1A antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-CD1A antibody

McNally, AK. et al. 2011. Exp. Mol. Pathol. 91: 673-681. Matsuda, A. et al. 2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877. Gulubova, M. et al. 2008. Clin. Exp. Metastasis. 25: 777-785. Cassaday, RD. et al. 2007. Clin. Cancer Res. 13: 540-549.

Other Notes

Small volumes of anti-CD1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD1A. It may not necessarily be applicable to this product.

NCBI GI #

1002167153

NCBI GeneID

909

NCBI Accession #

NP_001307581.1

UniProt Primary Accession #

P06126

UniProt Secondary Accession #

Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5; D3DVD7

UniProt Related Accession #

P06126

GenBank Nucleotide #

NM_001320652.1

NCBI Official Full Name

T-cell surface glycoprotein CD1a isoform 2

NCBI Official Synonym Full Names

CD1a molecule

NCBI Official Symbol

CD1A

NCBI Official Synonym Symbols

R4; T6; CD1; FCB6; HTA1

UniProt Protein Name

T-cell surface glycoprotein CD1a

UniProt Synonym Protein Names

T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a

Protein Family

T-cell surface glycoprotein

UniProt Gene Name

CD1A

UniProt Synonym Gene Names

hTa1 thymocyte antigen

UniProt Entry Name

CD1A_HUMAN

NCBI Protein Information

T-cell surface glycoprotein CD1a

NCBI Summary for CD1A

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

UniProt Comments for CD1A

CD1A: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: plasma membrane

Molecular Function: beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; protein binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response

Research Articles on CD1A

1. plasma-derived lipids drive functional levels of CD1d expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD1A antibody

Reference Product	PubMed Publications
CD83 antibody	>532 publications with CD1A and CD83
CD207 antibody	>124 publications with CD1A and CD207
KIRREL antibody	>1 publications with CD1A and KIRREL
B2M antibody	>1 publications with CD1A and B2M

Pathways associated with anti-CD1A antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CD1A antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>406 publications with CD1A and Lung Diseases
Necrosis Antibodies	>334 publications with CD1A and Necrosis
Inflammation Antibodies	>232 publications with CD1A and Inflammation
Cardiovascular Diseases Antibodies	>79 publications with CD1A and Cardiovascular Diseases
Liver Diseases Antibodies	>68 publications with CD1A and Liver Diseases
Fibrosis Antibodies	>65 publications with CD1A and Fibrosis
Death Antibodies	>62 publications with CD1A and Death
Hyperplasia Antibodies	>62 publications with CD1A and Hyperplasia
Lung Neoplasms Antibodies	>47 publications with CD1A and Lung Neoplasms
Breast Neoplasms Antibodies	>47 publications with CD1A and Breast Neoplasms

Organs/Tissues associated with anti-CD1A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1615 publications with CD1A and Blood
Skin Antibodies	>970 publications with CD1A and Skin
Lymph Node Antibodies	>309 publications with CD1A and Lymph Node
Lung Antibodies	>181 publications with CD1A and Lung
Thymus Antibodies	>120 publications with CD1A and Thymus
Brain Antibodies	>65 publications with CD1A and Brain
Heart Antibodies	>35 publications with CD1A and Heart