Mouse Anti-IFNA1 Monoclonal Antibody – Cat# MBS438530

Interferon Alpha-1 (IFNA1) Antibody – Mouse Monoclonal

Name: IFNA1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS438530
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438530

MBS438530 is an antibody targeting IFNA1. Also known as Interferon alpha-1 (IFNA1) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interferon alpha-1 (IFNA1), Monoclonal Antibody

Full Product Name

Interferon alpha-1 (IFNA1) Mouse Monoclonal Antibody

Product Gene Name

anti-IFNA1 antibody

Product Synonym Names

IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

2.52

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

16-27kDa

OMIM

147578

3D Structure

ModBase 3D Structure for P01562

Cellular Localization

Cytoplasmic & Extracellular (Secreted)

Immunogen

Purified recombinant human IFN-alpha1

Hu-Chromosome Location

9q22

Positive Control

Stimulated human peripheral blood mononuclear cells

Applications Tested/Suitable for anti-IFNA1 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Application Notes for anti-IFNA1 antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)

Product References and Citations for anti-IFNA1 antibody

Pestka S et al. Interferons and their actions. Annu Rev Biochem 1987, 56:727-777 Sen GC et al.The interferon system. A bird's eye view of its biochemistry. J Biol Chem 1992, 267(8):5017-5020 Capon DJ et al. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. Mol Cell Biol 1985, 5(4):768-779 Kurane I et al. Induction of interferon alpha from human lymphocytes by autologous, dengue virus-infected monocytes. J Exp Med 1987, 166(4):999-1010 Lepe-Zuniga JL et al. Production of interferon-alpha induced by dsRNA in human peripheral blood mononuclear cell cultures: role of priming by dsRNA-induced interferons-gamma and -beta. J Interferon Res 1989, 9(4):445-456 Aman MJ et al. Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes. Blood 1996, 87(11):4731-473

Other Notes

Small volumes of anti-IFNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNA1. It may not necessarily be applicable to this product.

NCBI GI #

194394174

NCBI GeneID

3447

NCBI Accession #

NP_008831.3

UniProt Primary Accession #

P01562

UniProt Secondary Accession #

Q14605; Q2M1L8; Q52LB8; Q5VYQ2; Q7M4Q1; Q8WZ68; Q9UMJ3; D4Q9M8

UniProt Related Accession #

P01562

GenBank Nucleotide #

NM_006900.3

NCBI Official Full Name

interferon alpha-1/13

NCBI Official Synonym Full Names

interferon alpha 13

NCBI Official Symbol

IFNA13

UniProt Protein Name

Interferon alpha-1/13

UniProt Synonym Protein Names

Interferon alpha-D; LeIF D

Protein Family

Interferon

UniProt Gene Name

IFNA1

UniProt Synonym Gene Names

IFN-alpha-1/13; LeIF D

UniProt Entry Name

IFNA1_HUMAN

NCBI Protein Information

interferon alpha-1/13

UniProt Comments for IFNA1

IFNA1/13: a cytokine that belongs to the alpha/beta interferon family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interferon-alpha/beta receptor binding

Biological Process: adaptive immune response; B cell differentiation; B cell proliferation; blood coagulation; cytokine and chemokine mediated signaling pathway; humoral immune response; innate immune response; natural killer cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to exogenous dsRNA; T cell activation during immune response

Research Articles on IFNA1

1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IFNA1 antibody

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Hepatitis B Pathway antibodies	Hepatitis B Pathway Diagram

Diseases associated with anti-IFNA1 antibody

Disease Name	Pubmed Publications
Cardiomyopathies Antibodies	>1 publications with IFNA1 and Cardiomyopathies
Cardiomegaly Antibodies	>1 publications with IFNA1 and Cardiomegaly
Neoplasms, Experimental Antibodies	>1 publications with IFNA1 and Neoplasms, Experimental
Kidney Diseases Antibodies	>1 publications with IFNA1 and Kidney Diseases
Cardiovascular Diseases Antibodies	>1 publications with IFNA1 and Cardiovascular Diseases
Heart Diseases Antibodies	>1 publications with IFNA1 and Heart Diseases
Colorectal Neoplasms Antibodies	>1 publications with IFNA1 and Colorectal Neoplasms
Adenocarcinoma Antibodies	>1 publications with IFNA1 and Adenocarcinoma
Melanoma Antibodies	>1 publications with IFNA1 and Melanoma
Carcinoma Antibodies	>1 publications with IFNA1 and Carcinoma