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CD16 / Fc-Gamma Receptor III (FCGR3A) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438590

MBS438590 is an antibody targeting FCGR3A. Also known as CD16 / Fc-gamma Receptor III Mouse Monoclonal Antibody. Reactive in Human.Others not tested. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD16 / Fc-gamma Receptor III (FCGR3A), Monoclonal Antibody
Full Product Name
CD16 / Fc-gamma Receptor III Mouse Monoclonal Antibody
Product Gene Name
anti-FCGR3A antibody
Product Synonym Names
FcRIIIa; FCR-10; FcRIII; FCGRIII; FcR-10; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); neutrophil-specific antigen NA; CD16a; low affinity immunoglobulin gamma Fc region receptor III-A; Fc-gamma RIIIa; immunoglobulin G Fc receptor III; Fc-gamma RIII-alpha; Fc-gamma receptor IIIb (CD16); CD16a antigen; Fc-gamma receptor III-2 (CD 16); FCGR3; Fc gamma receptor III-A; FCG3; low affinity III, receptor for (CD16); Fc-gamma RIII; IGFR3FcgammaRIIIA; CD16FCRIIIA; FCRIII; Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
HO-80
Host
Mouse
Species Reactivity
Human.
Others not tested
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
It recognizes CD16 (Fc gamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fc gamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gamma RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
50-80kDa
OMIM
146740
3D Structure
ModBase 3D Structure for P08637
Cellular Localization
Cell Surface
Immunogen
PBL s from a NK-leukemia patient
Hu-Chromosome Location
1q23
Positive Control
K-562 or U-937 cells. Lymph nodes and tonsils.
Applications Tested/Suitable for anti-FCGR3A antibody
Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-FCGR3A antibody
Functional Studies (Order Ab without BSA & Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)

Product References and Citations for anti-FCGR3A antibody

Knapp W. et al. (eds) Leukocyte Typing IV, Oxford University Press, Oxford, 1989. Lanier LL et al. Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16/Leu-11 antigen). J Exp Med 1985, 162(6):2089-2106

Other Notes

Small volumes of anti-FCGR3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR3A. It may not necessarily be applicable to this product.

NCBI GI #
50726979
NCBI GeneID
2214
NCBI Accession #
NP_000560.5
UniProt Primary Accession #
P08637
UniProt Secondary Accession #
Q53FJ0; Q53FL6; Q5EBR4; Q65ZM6; Q6PIJ0; A2N6W9
UniProt Related Accession #
P08637
GenBank Nucleotide #
NM_000569.6
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor III-A isoform a
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIIa
NCBI Official Symbol
FCGR3A
NCBI Official Synonym Symbols
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Synonym Protein Names
CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR3A
UniProt Synonym Gene Names
CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa
UniProt Entry Name
FCG3A_HUMAN
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor III-A

NCBI Summary for FCGR3A

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FCGR3A

FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: external side of plasma membrane; plasma membrane

Biological Process: immune response; regulation of immune response

Disease: Immunodeficiency 20
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Research Articles on FCGR3A

1. PAR-2 expression is increased on CD14++CD16+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCGR3A antibody

 Reference Product  PubMed Publications
 FCGR2A antibody  >95 publications with FCGR3A and FCGR2A
 FCGR2B antibody  >32 publications with FCGR3A and FCGR2B
 SYK antibody  >3 publications with FCGR3A and SYK
 PIK3CA antibody  >2 publications with FCGR3A and PIK3CA
 PIK3R1 antibody  >1 publications with FCGR3A and PIK3R1

Pathways associated with anti-FCGR3A antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram
 Leishmaniasis Pathway antibodies  Leishmaniasis Pathway Diagram

Diseases associated with anti-FCGR3A antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >33 publications with FCGR3A and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >28 publications with FCGR3A and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >25 publications with FCGR3A and Cardiovascular Diseases
 Inflammation Antibodies  >23 publications with FCGR3A and Inflammation
 Breast Neoplasms Antibodies  >17 publications with FCGR3A and Breast Neoplasms
 Leukemia Antibodies  >15 publications with FCGR3A and Leukemia
 Kidney Diseases Antibodies  >14 publications with FCGR3A and Kidney Diseases
 Neoplasms, Experimental Antibodies  >12 publications with FCGR3A and Neoplasms, Experimental
 Hemorrhage Antibodies  >8 publications with FCGR3A and Hemorrhage
 Disease Models, Animal Antibodies  >7 publications with FCGR3A and Disease Models, Animal

Organs/Tissues associated with anti-FCGR3A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >188 publications with FCGR3A and Blood
 Kidney Antibodies  >11 publications with FCGR3A and Kidney
 Lung Antibodies  >7 publications with FCGR3A and Lung
 Ovary Antibodies  >6 publications with FCGR3A and Ovary
 Liver Antibodies  >5 publications with FCGR3A and Liver
 Brain Antibodies  >3 publications with FCGR3A and Brain
 Spleen Antibodies  >2 publications with FCGR3A and Spleen
 Intestine Antibodies  >1 publications with FCGR3A and Intestine
 Thyroid Antibodies  >1 publications with FCGR3A and Thyroid
 Stomach Antibodies  >1 publications with FCGR3A and Stomach
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