• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Major Vault Protein (MVP) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438607

MBS438607 is an antibody targeting MVP. Also known as Major Vault Protein (MVP) Mouse Monoclonal Antibody. Reactive in Human.Others not tested. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Major Vault Protein (MVP), Monoclonal Antibody
Full Product Name
Major Vault Protein (MVP) Mouse Monoclonal Antibody
Product Gene Name
anti-MVP antibody
Product Synonym Names
Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
1032
Host
Mouse
Species Reactivity
Human.
Others not tested
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
104-110kDa
OMIM
605088
3D Structure
ModBase 3D Structure for Q14764
Cellular Localization
Cytoplasmic
Immunogen
Proteins precipitated from human breast cancer MCF-7 cells
Hu-Chromosome Location
16p11.2
Positive Control
MCF-7/HeLa, breast tumors
Applications Tested/Suitable for anti-MVP antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-MVP antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-MVP antibody

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MVP Monoclonal Antibody (1032).
Mouse Anti-MVP Monoclonal Antibody – Cat# MBS438607

Immunohistochemistry (IHC) of anti-MVP antibody

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MVP Monoclonal Antibody (1032).
Mouse Anti-MVP Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438607

Product References and Citations for anti-MVP antibody

Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA: Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 1998;141(6):1301-1310. Den Boer, M.L. et al. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 91, 2092-2098 (1998)

Other Notes

Small volumes of anti-MVP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.

NCBI GI #
645912958
NCBI GeneID
9961
NCBI Accession #
NP_001280133.1
UniProt Primary Accession #
Q14764
UniProt Secondary Accession #
Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1
UniProt Related Accession #
Q14764
GenBank Nucleotide #
NM_001293204.1
NCBI Official Full Name
major vault protein isoform 2
NCBI Official Synonym Full Names
major vault protein
NCBI Official Symbol
MVP
NCBI Official Synonym Symbols
LRP; VAULT1
UniProt Protein Name
Major vault protein
UniProt Synonym Protein Names
Lung resistance-related protein
Protein Family
Hyperpolarization-activated voltage-gated potassium channel
UniProt Gene Name
MVP
UniProt Synonym Gene Names
LRP; MVP
UniProt Entry Name
MVP_HUMAN
NCBI Protein Information
major vault protein

NCBI Summary for MVP

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Show more

UniProt Comments for MVP

MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytoskeleton; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; protein kinase binding; protein phosphatase binding

Biological Process: negative regulation of protein amino acid autophosphorylation
Show more

Research Articles on MVP

1. The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MVP antibody

 Reference Product  PubMed Publications
 TEP1 antibody  >21 publications with MVP and TEP1
 ABCB1 antibody  >14 publications with MVP and ABCB1
 PTEN antibody  >8 publications with MVP and PTEN
 TP53 antibody  >5 publications with MVP and TP53
 PTPN11 antibody  >1 publications with MVP and PTPN11
 RFWD2 antibody  >1 publications with MVP and RFWD2
 PARP4 antibody  >1 publications with MVP and PARP4

Diseases associated with anti-MVP antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >807 publications with MVP and Heart Diseases
 Lung Diseases Antibodies  >155 publications with MVP and Lung Diseases
 Lung Neoplasms Antibodies  >151 publications with MVP and Lung Neoplasms
 Hypertension Antibodies  >34 publications with MVP and Hypertension
 Fibrosis Antibodies  >33 publications with MVP and Fibrosis
 Disease Models, Animal Antibodies  >33 publications with MVP and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >33 publications with MVP and Neoplasm Metastasis
 Hypertrophy Antibodies  >30 publications with MVP and Hypertrophy
 Breast Neoplasms Antibodies  >27 publications with MVP and Breast Neoplasms
 Inflammation Antibodies  >22 publications with MVP and Inflammation

Organs/Tissues associated with anti-MVP antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >598 publications with MVP and Heart
 Blood Antibodies  >292 publications with MVP and Blood
 Lung Antibodies  >223 publications with MVP and Lung
 Vascular Antibodies  >131 publications with MVP and Vascular
 Brain Antibodies  >93 publications with MVP and Brain
 Muscle Antibodies  >70 publications with MVP and Muscle
 Bone Antibodies  >67 publications with MVP and Bone
 Connective Tissue Antibodies  >47 publications with MVP and Connective Tissue
 Liver Antibodies  >39 publications with MVP and Liver
 Bladder Antibodies  >35 publications with MVP and Bladder
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000