Mouse Anti-CD84 Monoclonal Antibody – Cat# MBS438678

CD84 Antibody – Mouse Monoclonal

Name: CD84 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS438678
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438678

MBS438678 is an antibody targeting CD84. Also known as CD84 / SLAMF5 Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD84 / SLAMF5, Monoclonal Antibody

Full Product Name

CD84 / SLAMF5 Mouse Monoclonal Antibody

Product Gene Name

anti-CD84 antibody

Product Synonym Names

Cell surface antigen MAX.3; hCD84; Hly9-beta; Leucocyte differentiation antigen CD84; LY9B; Signaling lymphocytic activation molecule 5 (SLAMF5); SLAM family member 5

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

153-4D9

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Recognizes a protein of 74kDa, identified as CD84. It is expressed on mature B cells and on B-cell lines, including pre-B-cell lines, but not on plasma cell lines. Immunohistochemical studies demonstrated that CD84 strongly expressed on tissues macrophages. CD84 is also highly expressed on platelets and, at low levels on peripheral blood T cells. It is a highly N-glycosylated protein and belongs to immunoglobulin superfamily. It may play a role in leukocyte activation.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

74kDa

OMIM

604513

3D Structure

ModBase 3D Structure for Q9UIB8

Cellular Localization

Cell Surface

Immunogen

MLR-stimulated lymphocytes

Hu-Chromosome Location

1q24

Positive Control

Raji, HL60, THP-1, HMC-1, HEL and NAMALWA cells. Human platelets and macrophages. Human tonsil.

Applications Tested/Suitable for anti-CD84 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Application Notes for anti-CD84 antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)

Product References and Citations for anti-CD84 antibody

Schlossman SF et al. (eds) Leukocyte Typing V. p.699-700, Oxford University Press, Oxford, 1995. de la Fuente MA et al. CD84 leukocyte antigen is a new member of the Ig superfamily. Blood 1997, 90(6):2398-2405. Kishimoto T. et al., eds. Leukocyte Typing VI, Garland Publishing, Inc, New York, 1997

Other Notes

Small volumes of anti-CD84 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD84. It may not necessarily be applicable to this product.

NCBI GI #

296434285

NCBI GeneID

8832

NCBI Accession #

NP_001171808.1

UniProt Primary Accession #

Q9UIB8

UniProt Secondary Accession #

O15430; O95266; O95660; Q5H9R1; Q6FHA8; Q8WLP1; Q8WWI8; Q9UF04; Q9UIB6; B2R8T1; B7Z3R8

UniProt Related Accession #

Q9UIB8

GenBank Nucleotide #

NM_001184879.1

NCBI Official Full Name

SLAM family member 5 isoform 1

NCBI Official Synonym Full Names

CD84 molecule

NCBI Official Symbol

CD84

NCBI Official Synonym Symbols

LY9B; hCD84; mCD84; SLAMF5

UniProt Protein Name

SLAM family member 5

UniProt Synonym Protein Names

Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84

Protein Family

SLAM family

UniProt Gene Name

CD84

UniProt Synonym Gene Names

SLAMF5

UniProt Entry Name

SLAF5_HUMAN

NCBI Protein Information

SLAM family member 5

NCBI Summary for CD84

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

UniProt Comments for CD84

CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: defense response; homophilic cell adhesion; leukocyte migration; negative regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of interleukin-18 production; negative regulation of mast cell activation; negative regulation of mast cell degranulation

Research Articles on CD84

1. up-regulated in Kawasaki disease arteriopathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD84 antibody

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with anti-CD84 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>3 publications with CD84 and Cardiovascular Diseases
Inflammation Antibodies	>3 publications with CD84 and Inflammation
Nervous System Diseases Antibodies	>2 publications with CD84 and Nervous System Diseases
Necrosis Antibodies	>2 publications with CD84 and Necrosis
Disease Models, Animal Antibodies	>1 publications with CD84 and Disease Models, Animal
Liver Neoplasms Antibodies	>1 publications with CD84 and Liver Neoplasms

Organs/Tissues associated with anti-CD84 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>52 publications with CD84 and Blood
Bone Antibodies	>10 publications with CD84 and Bone
Spleen Antibodies	>7 publications with CD84 and Spleen
Lymph Node Antibodies	>6 publications with CD84 and Lymph Node
Lymph Antibodies	>4 publications with CD84 and Lymph
Tonsil Antibodies	>4 publications with CD84 and Tonsil
Pharynx Antibodies	>3 publications with CD84 and Pharynx
Liver Antibodies	>3 publications with CD84 and Liver
Lung Antibodies	>2 publications with CD84 and Lung
Testis Antibodies	>1 publications with CD84 and Testis