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Cytokeratin 19 (KRT19) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438688

MBS438688 is an antibody targeting KRT19. Also known as Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker) Mouse Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Cytokeratin 19 (KRT19), Monoclonal Antibody
Full Product Name
Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker) Mouse Monoclonal Antibody
Product Gene Name
anti-KRT19 antibody
Product Synonym Names
k19; k1cs; Keratin 19 Keratin Type i 40kD; KRT19
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
KRT19/800
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a protein of 40kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
40kDa
OMIM
148020
3D Structure
ModBase 3D Structure for P08727
Cellular Localization
Cytoplasmic
Immunogen
Recombinant human KRT19 protein
Hu-Chromosome Location
17q21.2
Positive Control
MCF-7, HeLa cells, Breast Cancer
Applications Tested/Suitable for anti-KRT19 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-KRT19 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded Rat Stomach stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded Rat Colon stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded Rat Lung stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Immunohistochemistry (IHC) of anti-KRT19 antibody

Formalin-fixed, paraffin-embedded human Pancreas stained with Cytokeratin 19 Monoclonal Antibody (KRT19/800)
Mouse Anti-KRT19 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438688

Product References and Citations for anti-KRT19 antibody

Van Eyken, P., et al. 1991. Immunocytochemistry of cytokeratins in primary human liver tumors. APMIS Suppl. 23: 77-85. van der Velden, L.A., et al. 1993. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview. Head Neck 15: 133-146.

Other Notes

Small volumes of anti-KRT19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT19. It may not necessarily be applicable to this product.

NCBI GI #
24234699
NCBI GeneID
3880
NCBI Accession #
NP_002267.2
UniProt Primary Accession #
P08727
UniProt Secondary Accession #
Q5XG83; Q6NW33; Q7L5M9; Q96A53; Q96FV1; Q9BYF9; Q9P1Y4; B2R874
UniProt Related Accession #
P08727
GenBank Nucleotide #
NM_002276.4
NCBI Official Full Name
keratin, type I cytoskeletal 19
NCBI Official Synonym Full Names
keratin 19
NCBI Official Symbol
KRT19
NCBI Official Synonym Symbols
K19; CK19; K1CS
UniProt Protein Name
Keratin, type I cytoskeletal 19
UniProt Synonym Protein Names
Cytokeratin-19; CK-19; Keratin-19; K19
Protein Family
Keratin
UniProt Gene Name
KRT19
UniProt Synonym Gene Names
CK-19; K19
UniProt Entry Name
K1C19_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 19

NCBI Summary for KRT19

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
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UniProt Comments for KRT19

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: costamere; plasma membrane

Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle

Biological Process: response to estrogen stimulus; sarcomere organization
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Research Articles on KRT19

1. When confirmed by a low alpha-fetoprotein concentration (<400 mug/L), CK-19 expression in is an additional valuable indicator of early recurrence, distant metastasis, and poor prognosis in HBV-positive patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KRT19 antibody

 Products by Pathway  Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram

Diseases associated with anti-KRT19 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >21 publications with KRT19 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >19 publications with KRT19 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >19 publications with KRT19 and Breast Neoplasms
 Liver Diseases Antibodies  >18 publications with KRT19 and Liver Diseases
 Liver Neoplasms Antibodies  >12 publications with KRT19 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >9 publications with KRT19 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >7 publications with KRT19 and Fibrosis
 Lung Neoplasms Antibodies  >5 publications with KRT19 and Lung Neoplasms
 Neoplasm Invasiveness Antibodies  >5 publications with KRT19 and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >5 publications with KRT19 and Neoplasms, Experimental

Organs/Tissues associated with anti-KRT19 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with KRT19 and Liver
 Blood Antibodies  >22 publications with KRT19 and Blood
 Bone Antibodies  >19 publications with KRT19 and Bone
 Lung Antibodies  >8 publications with KRT19 and Lung
 Eye Antibodies  >5 publications with KRT19 and Eye
 Lymph Antibodies  >5 publications with KRT19 and Lymph
 Skin Antibodies  >5 publications with KRT19 and Skin
 Thyroid Antibodies  >5 publications with KRT19 and Thyroid
 Lymph Node Antibodies  >5 publications with KRT19 and Lymph Node
 Salivary Gland Antibodies  >4 publications with KRT19 and Salivary Gland
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