Mouse Anti-TRIM29 Monoclonal Antibody – Cat# MBS438746

Western Blot of TRIM29 Recombinant protein fragment & A431 Cell Lysate TRIM29 Monoclonal Antibody (TRIM29/1042).

TRIM29 Antibody – Mouse Monoclonal

Name: TRIM29 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS438746
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438746

MBS438746 is an antibody targeting TRIM29. Also known as TRIM29 (Lung Squamous Cell Carcinoma Marker) Mouse Monoclonal Antibody. Reactive in Human.Others not known. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRIM29, Monoclonal Antibody

Full Product Name

TRIM29 (Lung Squamous Cell Carcinoma Marker) Mouse Monoclonal Antibody

Product Gene Name

anti-TRIM29 antibody

Product Synonym Names

Ataxia telangiectasia group D complementing gene (ATDC); Tripartite motif-containing protein 29 (TRIM29);

Clonality

Monoclonal

Isotype

IgG2b, kappa

Clone Number

TRIM29/1042

Host

Mouse

Species Reactivity

Human.
Others not known

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

66kDa

OMIM

610658

3D Structure

ModBase 3D Structure for Q14134

Cellular Localization

Cytoplasmic & Cell Surface

Immunogen

Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein

Hu-Chromosome Location

11q23.3

Positive Control

A431 cells. Tonsil or Squamous cell carcinoma.

Applications Tested/Suitable for anti-TRIM29 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

Application Notes for anti-TRIM29 antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)

Product References and Citations for anti-TRIM29 antibody

Kosaka Y, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14(9): 2543-9. 2007. Ring BZ, et al. A novel five-antibody immunohistochemical test for sub-classification of lung carcinoma. Mod Pathol. 22(8): 1032-43. 2009

Other Notes

Small volumes of anti-TRIM29 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM29. It may not necessarily be applicable to this product.

NCBI GI #

17402909

NCBI GeneID

23650

NCBI Accession #

NP_036233.2

UniProt Primary Accession #

Q14134

UniProt Secondary Accession #

Q96AA9; Q9BZY7

UniProt Related Accession #

Q14134

GenBank Nucleotide #

NM_012101.3

NCBI Official Full Name

tripartite motif-containing protein 29

NCBI Official Synonym Full Names

tripartite motif containing 29

NCBI Official Symbol

TRIM29

NCBI Official Synonym Symbols

ATDC

UniProt Protein Name

Tripartite motif-containing protein 29

UniProt Synonym Protein Names

Ataxia telangiectasia group D-associated protein

Protein Family

Tripartite motif-containing protein

UniProt Gene Name

TRIM29

UniProt Synonym Gene Names

ATDC

UniProt Entry Name

TRI29_HUMAN

NCBI Protein Information

tripartite motif-containing protein 29

NCBI Summary for TRIM29

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

UniProt Comments for TRIM29

TRIM29: It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line. Interacts with VIM and HINT1. Expressed in placenta, prostate and thymus. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: cytoplasm; intermediate filament cytoskeleton; nucleoplasm

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter

Research Articles on TRIM29

1. Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIM29 antibody

Reference Product	PubMed Publications
KAT5 antibody	>2 publications with TRIM29 and KAT5
TP53 antibody	>1 publications with TRIM29 and TP53

Pathways associated with anti-TRIM29 antibody

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
Interferon Gamma Signaling Pathway antibodies	Interferon Gamma Signaling Pathway Diagram

Diseases associated with anti-TRIM29 antibody

Disease Name	Pubmed Publications
Ataxia Antibodies	>20 publications with TRIM29 and Ataxia
Lung Neoplasms Antibodies	>8 publications with TRIM29 and Lung Neoplasms
Lung Diseases Antibodies	>7 publications with TRIM29 and Lung Diseases
Cell Transformation, Neoplastic Antibodies	>7 publications with TRIM29 and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>6 publications with TRIM29 and Nervous System Diseases
Breast Neoplasms Antibodies	>6 publications with TRIM29 and Breast Neoplasms
Skin Diseases Antibodies	>6 publications with TRIM29 and Skin Diseases
Disease Models, Animal Antibodies	>3 publications with TRIM29 and Disease Models, Animal
Inflammation Antibodies	>3 publications with TRIM29 and Inflammation
Precancerous Conditions Antibodies	>1 publications with TRIM29 and Precancerous Conditions

Organs/Tissues associated with anti-TRIM29 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>10 publications with TRIM29 and Lung
Prostate Antibodies	>6 publications with TRIM29 and Prostate
Bladder Antibodies	>4 publications with TRIM29 and Bladder
Stomach Antibodies	>3 publications with TRIM29 and Stomach
Skin Antibodies	>3 publications with TRIM29 and Skin
Muscle Antibodies	>2 publications with TRIM29 and Muscle
Pancreas Antibodies	>1 publications with TRIM29 and Pancreas
Esophagus Antibodies	>1 publications with TRIM29 and Esophagus
Eye Antibodies	>1 publications with TRIM29 and Eye
Blood Antibodies	>1 publications with TRIM29 and Blood