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IPO-38 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS438808

MBS438808 is an antibody targeting IPO-38. Also known as IPO-38 (Proliferation Marker) Mouse Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IPO-38, Monoclonal Antibody
Full Product Name
IPO-38 (Proliferation Marker) Mouse Monoclonal Antibody
Product Gene Name
anti-IPO-38 antibody
Clonality
Monoclonal
Isotype
IgM, kappa
Clone Number
IPO-38
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a protein of 14-16kDa, which is a novel nuclear antigen of proliferating cells. IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin's disease and non-Hodgkin's lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO-38 may be a useful marker of cell proliferation during monitoring of tumor progression.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
14-16kDa
Cellular Localization
Nuclear
Immunogen
Spleen cells of a patient with hairy cell leukemia
Positive Control
Raji and PHA-stimulated (>12 hours) human or mouse lymphocytes. Breast and colorectal carcinomas.
Applications Tested/Suitable for anti-IPO-38 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-IPO-38 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-IPO-38 antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with IPO-38 Monoclonal Antibody.
Mouse Anti-IPO-38 Monoclonal Antibody – Cat# MBS438808

Immunohistochemistry (IHC) of anti-IPO-38 antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with IPO-38 Monoclonal Antibody.
Mouse Anti-IPO-38 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS438808

Product References and Citations for anti-IPO-38 antibody

Sidorenko SP et al. Monoclonal antibodies of the IPO series in studying and diagnosing malignant lympho-proliferative diseases. Gematol Transfuziol 1990, 35(4):19-22. Mikhalap SV et al. Monoclonal antibody IPO-38 recognizes a novel nuclear antigen of proliferating cells. In Kishimoto T et al eds. Leukocyte Typing VI, p609-610, Garland Publishing, New York, 1997.Mathews MB et al. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984, 309:374-376

Other Notes

Small volumes of anti-IPO-38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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