Mouse Anti-LHB Monoclonal Antibody – Cat# MBS439102

Formalin-fixed, paraffin-embedded human Pituitary stained with LH-beta Monoclonal Antibody (SPM103).

Lh-Beta (Luteinizing Hormone-Beta) (LHB) Antibody – Mouse Monoclonal

Name: LHB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439102
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439102

MBS439102 is an antibody targeting LHB. Also known as LH-beta (Luteinizing Hormone-beta) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LH-beta (Luteinizing Hormone-beta) (LHB), Monoclonal Antibody

Full Product Name

LH-beta (Luteinizing Hormone-beta) Mouse Monoclonal Antibody

Product Gene Name

anti-LHB antibody

Product Synonym Names

CHORIONIC GONADOTROPIN, BETA POLYPEPTIDE 4 (CGB4); hLHB; Interstitial cell stimulating hormone beta chain; Leutropin; LH-B; LHB; LSH-B; LSH-beta; Luteinizing hormone beta polypeptide; Luteinizing hormone subunit beta; Lutropin beta chain; Lutropin subunit beta

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

SPM103

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule; two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

22kDa

OMIM

152780

3D Structure

ModBase 3D Structure for P01229

Cellular Localization

Cytoplasmic, Secreted

Immunogen

Recombinant beta sub-unit of human LH

Hu-Chromosome Location

19q13.32

Positive Control

Anterior Pituitary

Applications Tested/Suitable for anti-LHB antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-LHB antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml; 30 min RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-LHB antibody

Couzinet, B., et al. 1993. The control of gonadotrophin secretion by ovarian steroids. Hum. Reprod. 2: 97-101

Other Notes

Small volumes of anti-LHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LHB. It may not necessarily be applicable to this product.

NCBI GI #

4504989

NCBI GeneID

3972

NCBI Accession #

NP_000885.1

UniProt Primary Accession #

P01229

UniProt Secondary Accession #

Q9UDI0

UniProt Related Accession #

P01229

GenBank Nucleotide #

NM_000894.2

NCBI Official Full Name

lutropin subunit beta

NCBI Official Synonym Full Names

luteinizing hormone beta polypeptide

NCBI Official Symbol

LHB

NCBI Official Synonym Symbols

CGB4; HH23; LSH-B; LSH-beta

UniProt Protein Name

Lutropin subunit beta

UniProt Synonym Protein Names

Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta

Protein Family

Lutropin/choriogonadotropin

UniProt Gene Name

LHB

UniProt Synonym Gene Names

Lutropin beta chain; LH-B; LSH-B; LSH-beta

UniProt Entry Name

LSHB_HUMAN

NCBI Protein Information

lutropin subunit beta

NCBI Summary for LHB

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

UniProt Comments for LHB

LHB: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Defects in LHB are a cause of hypogonadism LHB-related (HGON-LHB). Hypogonadism is characterized by infertility and pseudohermaphroditism. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: extracellular region; Golgi lumen

Molecular Function: receptor binding

Biological Process: cell-cell signaling; male gonad development; peptide hormone processing; progesterone biosynthetic process; signal transduction

Disease: Fertile Eunuch Syndrome

Research Articles on LHB

1. The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LHB antibody

Reference Product	PubMed Publications
CGA antibody	>37 publications with LHB and CGA
EGR1 antibody	>14 publications with LHB and EGR1
LHCGR antibody	>11 publications with LHB and LHCGR
CYP17A1 antibody	>7 publications with LHB and CYP17A1
POMC antibody	>6 publications with LHB and POMC
FOXO1 antibody	>2 publications with LHB and FOXO1

Pathways associated with anti-LHB antibody

Products by Pathway	Pathway Diagram
Androgen Biosynthesis Pathway antibodies	Androgen Biosynthesis Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Glycoprotein Hormones Pathway antibodies	Glycoprotein Hormones Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
Hormone Ligand-binding Receptors Pathway antibodies	Hormone Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-LHB antibody

Disease Name	Pubmed Publications
Pain Antibodies	>63 publications with LHB and Pain
Nervous System Diseases Antibodies	>48 publications with LHB and Nervous System Diseases
Cardiovascular Diseases Antibodies	>36 publications with LHB and Cardiovascular Diseases
Heart Diseases Antibodies	>22 publications with LHB and Heart Diseases
Depressive Disorder Antibodies	>9 publications with LHB and Depressive Disorder
Myocardial Infarction Antibodies	>8 publications with LHB and Myocardial Infarction
Hypogonadism Antibodies	>7 publications with LHB and Hypogonadism
Hyperplasia Antibodies	>7 publications with LHB and Hyperplasia
Infertility, Female Antibodies	>7 publications with LHB and Infertility, Female
Inflammation Antibodies	>7 publications with LHB and Inflammation

Organs/Tissues associated with anti-LHB antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>265 publications with LHB and Brain
Pituitary Gland Antibodies	>84 publications with LHB and Pituitary Gland
Placenta Antibodies	>7 publications with LHB and Placenta
Embryonic Tissue Antibodies	>6 publications with LHB and Embryonic Tissue