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TOX3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439154

MBS439154 is an antibody targeting TOX3. Also known as TOX3 / TNRC9 Mouse Monoclonal Antibody. Reactive in Human.Others not known. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TOX3 / TNRC9, Monoclonal Antibody
Full Product Name
TOX3 / TNRC9 Mouse Monoclonal Antibody
Product Gene Name
anti-TOX3 antibody
Product Synonym Names
TOX3; CAG trinucleotide repeat-containing gene F9 protein; CAGF9; TOX high mobility group box family member 3; Trinucleotide repeat containing 9 (TNRC9)
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
TOX3/1124
Host
Mouse
Species Reactivity
Human.
Others not known
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
63kDa
OMIM
611416
3D Structure
ModBase 3D Structure for O15405
Cellular Localization
Cytoplasmic & Nuclear
Immunogen
Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein
Hu-Chromosome Location
16q12.1
Positive Control
SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.
Applications Tested/Suitable for anti-TOX3 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-TOX3 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)

Western Blot (WB) of anti-TOX3 antibody

Western Blot Analysis(A) Recombinant protein (B) A549 (C) A431 stained with TOX3 Monoclonal Antibody (TOX3/1124).
Mouse Anti-TOX3 Monoclonal Antibody – Cat# MBS439154

Product References and Citations for anti-TOX3 antibody

O'Flaherty, E., et al. 2003. TOX defines a conserved subfamily of HMG-box proteins. BMC Genomics 4: 13. Smid, M., et al. 2006. Genes associated with breast cancer metastatic to bone. J. Clin. Oncol. 24: 2261-2267.

Other Notes

Small volumes of anti-TOX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TOX3. It may not necessarily be applicable to this product.

NCBI GI #
226054295
NCBI GeneID
27324
NCBI Accession #
NP_001073899.2
UniProt Primary Accession #
O15405
UniProt Secondary Accession #
B4DRD0; B5MCW4
UniProt Related Accession #
O15405
GenBank Nucleotide #
NM_001080430.3
NCBI Official Full Name
TOX high mobility group box family member 3 isoform 1
NCBI Official Synonym Full Names
TOX high mobility group box family member 3
NCBI Official Symbol
TOX3
NCBI Official Synonym Symbols
CAGF9; TNRC9
UniProt Protein Name
TOX high mobility group box family member 3
UniProt Synonym Protein Names
CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein
Protein Family
TOX high mobility group box family
UniProt Gene Name
TOX3
UniProt Synonym Gene Names
CAGF9; TNRC9
UniProt Entry Name
TOX3_HUMAN
NCBI Protein Information
TOX high mobility group box family member 3

NCBI Summary for TOX3

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
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UniProt Comments for TOX3

TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q12.1

Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activity

Biological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent
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Research Articles on TOX3

1. TOX3 and FGFR2 are breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TOX3 antibody

 Reference Product  PubMed Publications
 FGFR2 antibody  >32 publications with TOX3 and FGFR2
 MAP3K1 antibody  >18 publications with TOX3 and MAP3K1
 LSP1 antibody  >18 publications with TOX3 and LSP1
 MRPS30 antibody  >6 publications with TOX3 and MRPS30
 RAD51B antibody  >2 publications with TOX3 and RAD51B
 FOS antibody  >1 publications with TOX3 and FOS

Diseases associated with anti-TOX3 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >52 publications with TOX3 and Breast Neoplasms
 Breast Neoplasms, Male Antibodies  >9 publications with TOX3 and Breast Neoplasms, Male
 Nervous System Diseases Antibodies  >5 publications with TOX3 and Nervous System Diseases
 Lung Neoplasms Antibodies  >3 publications with TOX3 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with TOX3 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >2 publications with TOX3 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with TOX3 and Inflammation
 Hypertension Antibodies  >1 publications with TOX3 and Hypertension
 Nerve Degeneration Antibodies  >1 publications with TOX3 and Nerve Degeneration
 Kidney Diseases Antibodies  >1 publications with TOX3 and Kidney Diseases
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