• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Ksp-Cadherin (Kidney-Specific Cadherin)/CDH16 (CDH16) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439203

MBS439203 is an antibody targeting CDH16. Also known as Ksp-Cadherin (Kidney-Specific Cadherin)/CDH16. Reactive in Human, Mouse, Rat, Rabbit, Dog. Others not known.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ksp-Cadherin (Kidney-Specific Cadherin)/CDH16, Monoclonal Antibody
Full Product Name
Ksp-Cadherin (Kidney-Specific Cadherin)/CDH16
Product Gene Name
anti-CDH16 antibody
Product Synonym Names
Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
rCDH16/1071
Host
Mouse
Species Reactivity
Human, Mouse, Rat, Rabbit, Dog. Others not known.
Form/Format
200ug/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
130kDa
3D Structure
ModBase 3D Structure for O75309
Immunogen
Recombinant full-length human CDH16 protein
Cellular Localization
Cell Surface with some Cytoplasmic
Hu-chromosome Location
16q22.1
Positive Control
Normal kidney or renal cell carcinoma.
Applications Tested/Suitable for anti-CDH16 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-CDH16 antibody
FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-CDH16 antibody

Formalin-fixed, paraffin-embedded Human Renal Cell Carcinoma stained with KSP-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH16/1071).
Mouse Anti-CDH16 Monoclonal Antibody – Cat# MBS439203

SDS-Page of anti-CDH16 antibody

SDS-PAGE Analysis of Purified KSP-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH16/1071).
Mouse Anti-CDH16 Monoclonal Antibody, SDS-Page – Cat# MBS439203

Product References and Citations for anti-CDH16 antibody

Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28. Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40.

Other Notes

Small volumes of anti-CDH16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH16. It may not necessarily be applicable to this product.

NCBI GI #
325296969
NCBI GeneID
1014
NCBI Accession #
NP_001191673.1
UniProt Primary Accession #
O75309
UniProt Secondary Accession #
Q6UW93; B4DPA8; H3BPD3
UniProt Related Accession #
O75309
GenBank Nucleotide #
NM_001204744.1
NCBI Official Full Name
cadherin-16 isoform 2
NCBI Official Synonym Full Names
cadherin 16
NCBI Official Symbol
CDH16
UniProt Protein Name
Cadherin-16
UniProt Synonym Protein Names
Kidney-specific cadherin; Ksp-cadherin
Protein Family
Cadherin
UniProt Gene Name
CDH16
UniProt Synonym Gene Names
Ksp-cadherin
NCBI Protein Information
cadherin-16

NCBI Summary for CDH16

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Show more

UniProt Comments for CDH16

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Research Articles on CDH16

1. Our study expands the clinical and allelic spectrum of known Retinal dystrophies genes, and reveals AGBL5, CDH16, and DNAJC17 as novel disease candidates.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDH16 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >1 publications with CDH16 and CTNNB1

Diseases associated with anti-CDH16 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with CDH16 and Neoplasms
 Kidney Diseases Antibodies  >13 publications with CDH16 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CDH16 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with CDH16 and Liver Diseases
 Nervous System Diseases Antibodies  >1 publications with CDH16 and Nervous System Diseases
 Bone Diseases Antibodies  >1 publications with CDH16 and Bone Diseases

Organs/Tissues associated with anti-CDH16 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >27 publications with CDH16 and Kidney
 Thyroid Antibodies  >3 publications with CDH16 and Thyroid
 Muscle Antibodies  >1 publications with CDH16 and Muscle
 Brain Antibodies  >1 publications with CDH16 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000