Mouse Anti-FSHB Monoclonal Antibody – Cat# MBS439339

Formalin-fixed, paraffin-embedded human Pituitary stained with FSH-beta Monoclonal Antibody (SPM107).

FSH-Beta (Follicle Stimulating Hormone-Beta) (FSHB) Antibody – Mouse Monoclonal

Name: FSHB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439339
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439339

MBS439339 is an antibody targeting FSHB. Also known as FSH-beta (Follicle Stimulating Hormone-beta) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FSH-beta (Follicle Stimulating Hormone-beta) (FSHB), Monoclonal Antibody

Full Product Name

FSH-beta (Follicle Stimulating Hormone-beta) Mouse Monoclonal Antibody

Product Gene Name

anti-FSHB antibody

Product Synonym Names

Follicle stimulating hormone beta polypeptide; Follicle stimulating hormone beta subunit; Follitropin beta chain; Follitropin subunit beta; FSH-B; FSH-beta; FSHB; FSHbeta

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

SPM107

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

This MAb reacts with a protein of 22kDa, identified as beta sub-unit of FSH. It does not cross react with the alpha sub-unit. Follicle stimulating hormone (FSH) is a hormone synthesized and secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testis and is critical for spermatogenesis. FSH and LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors and the study of pituitary disease.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

22kDa

OMIM

136530

3D Structure

ModBase 3D Structure for P01225

Cellular Localization

Cytoplasmic, Secreted

Immunogen

Full length purified Human FSH

Hu-Chromosome Location

11p13

Positive Control

Anterior Pituitary

Applications Tested/Suitable for anti-FSHB antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-FSHB antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml; 30 min RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-FSHB antibody

Schmidt M et al. Pathol Res Pract. 2001;197(10):663-9 La Rosa S et al. Virchows Arch. 2000 Sep;437(3):264-9 Zheng W et al. Gynecol Oncol. 2000 jan;76(1):80-8

Other Notes

Small volumes of anti-FSHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FSHB. It may not necessarily be applicable to this product.

NCBI GI #

4503791

NCBI GeneID

2488

NCBI Accession #

NP_000501.1

UniProt Primary Accession #

P01225

UniProt Secondary Accession #

Q14D61; A2TF08; A5JVV3

UniProt Related Accession #

P01225

GenBank Nucleotide #

NM_000510.2

NCBI Official Full Name

follitropin subunit beta

NCBI Official Synonym Full Names

follicle stimulating hormone beta subunit

NCBI Official Symbol

FSHB

NCBI Official Synonym Symbols

HH24

UniProt Protein Name

Follitropin subunit beta

UniProt Synonym Protein Names

Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain

Protein Family

Follitropin

UniProt Gene Name

FSHB

UniProt Synonym Gene Names

FSH-B; FSH-beta

UniProt Entry Name

FSHB_HUMAN

NCBI Protein Information

follitropin subunit beta

NCBI Summary for FSHB

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for FSHB

FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function: follicle-stimulating hormone activity; hormone activity; protein binding

Biological Process: female gamete generation; female pregnancy; peptide hormone processing; progesterone biosynthetic process; signal transduction; transforming growth factor beta receptor signaling pathway

Disease: Follicle-stimulating Hormone Deficiency, Isolated

Research Articles on FSHB

1. The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FSHB antibody

Reference Product	PubMed Publications
FSHR antibody	>40 publications with FSHB and FSHR
CGA antibody	>34 publications with FSHB and CGA
INHA antibody	>4 publications with FSHB and INHA
INHBB antibody	>3 publications with FSHB and INHBB
INHBA antibody	>1 publications with FSHB and INHBA

Pathways associated with anti-FSHB antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
FSH Signaling Pathway antibodies	FSH Signaling Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Glycoprotein Hormones Pathway antibodies	Glycoprotein Hormones Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
Hormone Ligand-binding Receptors Pathway antibodies	Hormone Ligand-binding Receptors Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram

Diseases associated with anti-FSHB antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>25 publications with FSHB and Infertility, Male
Infertility, Female Antibodies	>15 publications with FSHB and Infertility, Female
Kidney Diseases Antibodies	>10 publications with FSHB and Kidney Diseases
Hypogonadism Antibodies	>8 publications with FSHB and Hypogonadism
Nervous System Diseases Antibodies	>5 publications with FSHB and Nervous System Diseases
Oligospermia Antibodies	>3 publications with FSHB and Oligospermia
Breast Neoplasms Antibodies	>2 publications with FSHB and Breast Neoplasms
Hypertension Antibodies	>1 publications with FSHB and Hypertension
Prenatal Exposure Delayed Effects Antibodies	>1 publications with FSHB and Prenatal Exposure Delayed Effects
Follicle-stimulating hormone deficiency, isolated Antibodies	>1 publications with FSHB and Follicle-stimulating hormone deficiency, isolated

Organs/Tissues associated with anti-FSHB antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>103 publications with FSHB and Brain
Pituitary Gland Antibodies	>90 publications with FSHB and Pituitary Gland
Testis Antibodies	>34 publications with FSHB and Testis