Mouse Anti-SHBG Monoclonal Antibody – Cat# MBS439386

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with SHBG Monoclonal Antibody (SHBG/245)

Sex Hormone Binding Globulin (SHBG) Antibody – Mouse Monoclonal

Name: SHBG Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439386
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439386

MBS439386 is an antibody targeting SHBG. Also known as Sex Hormone Binding Globulin (SHBG) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sex Hormone Binding Globulin (SHBG), Monoclonal Antibody

Full Product Name

Sex Hormone Binding Globulin (SHBG) Mouse Monoclonal Antibody

Product Gene Name

anti-SHBG antibody

Product Synonym Names

Androgen binding protein (ABP); Sex hormone-binding globulin (SHBG); Sex steroid binding protein (SBP); Sex steroid-binding protein; Testis-specific androgen-binding protein; Testosterone binding beta globulin; Testosterone-Estradiol-Binding Globulin (TEBG)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

SHBG/245

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Recognizes a protein of 45kDa, identified as SHBG. It functions as an androgen transport protein, but may also be involved in receptor-mediated processes. Each dimer binds one molecule of steroid. It is specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

45kDa

OMIM

182205

3D Structure

ModBase 3D Structure for P04278

Cellular Localization

Cytoplasmic & Extracellular (Secreted)

Immunogen

Recombinant full-length human SHBG protein

Hu-Chromosome Location

17p13.1

Positive Control

Liver, Placenta or Testis

Applications Tested/Suitable for anti-SHBG antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-SHBG antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-SHBG antibody

Grishkovskaya, I., et al. 2000. Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain. EMBO. J. 19: 504-512.

Other Notes

Small volumes of anti-SHBG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SHBG. It may not necessarily be applicable to this product.

NCBI GI #

7382460

NCBI GeneID

6462

NCBI Accession #

NP_001031.2

UniProt Primary Accession #

P04278

UniProt Secondary Accession #

P14689; Q16616; Q3MIL0; Q6ISD2; B0FWH4; E9PGW1; F5H5Z8; I3L1N7

UniProt Related Accession #

P04278

GenBank Nucleotide #

NM_001040.4

NCBI Official Full Name

sex hormone-binding globulin isoform 1

NCBI Official Synonym Full Names

sex hormone binding globulin

NCBI Official Symbol

SHBG

NCBI Official Synonym Symbols

ABP; SBP; TEBG

UniProt Protein Name

Sex hormone-binding globulin

UniProt Synonym Protein Names

Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin

Protein Family

Sex hormone-binding globulin

UniProt Gene Name

SHBG

UniProt Synonym Gene Names

SHBG; SBP; ABP; TeBG

UniProt Entry Name

SHBG_HUMAN

NCBI Protein Information

sex hormone-binding globulin

NCBI Summary for SHBG

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

UniProt Comments for SHBG

SHBG: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13.1

Molecular Function: androgen binding

Research Articles on SHBG

1. Data suggest that, in endurance runners using endurance training followed by strength training, an initial reduction in testosterone/SHBG ratio is seen after 12 weeks followed by large increase in weeks 12-24 (as compared to endurance training alone).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHBG antibody

Reference Product	PubMed Publications
CYP19A1 antibody	>164 publications with SHBG and CYP19A1
IGF1 antibody	>21 publications with SHBG and IGF1
INS antibody	>18 publications with SHBG and INS
IGFBP1 antibody	>11 publications with SHBG and IGFBP1
HNF4A antibody	>7 publications with SHBG and HNF4A
GNRH1 antibody	>2 publications with SHBG and GNRH1
SERPINA6 antibody	>2 publications with SHBG and SERPINA6
LEP antibody	>1 publications with SHBG and LEP
SULT2A1 antibody	>1 publications with SHBG and SULT2A1

Pathways associated with anti-SHBG antibody

Products by Pathway	Pathway Diagram
Nongenotropic Androgen Signaling Pathway antibodies	Nongenotropic Androgen Signaling Pathway Diagram

Diseases associated with anti-SHBG antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>568 publications with SHBG and Breast Neoplasms
Congenital Abnormalities Antibodies	>376 publications with SHBG and Congenital Abnormalities
Disorders of Sex Development Antibodies	>364 publications with SHBG and Disorders of Sex Development
Prostatic Neoplasms Antibodies	>262 publications with SHBG and Prostatic Neoplasms
Weight Loss Antibodies	>237 publications with SHBG and Weight Loss
Diabetes Mellitus, Type 2 Antibodies	>233 publications with SHBG and Diabetes Mellitus, Type 2
Metabolic Syndrome X Antibodies	>197 publications with SHBG and Metabolic Syndrome X
Hyperplasia Antibodies	>183 publications with SHBG and Hyperplasia
Infertility, Male Antibodies	>171 publications with SHBG and Infertility, Male
Infertility, Female Antibodies	>162 publications with SHBG and Infertility, Female

Organs/Tissues associated with anti-SHBG antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>565 publications with SHBG and Liver
Brain Antibodies	>358 publications with SHBG and Brain
Testis Antibodies	>335 publications with SHBG and Testis
Eye Antibodies	>15 publications with SHBG and Eye
Intestine Antibodies	>13 publications with SHBG and Intestine