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Tyrosinase-Related Protein-1 (TYRP-1) (TYRP1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439395

MBS439395 is an antibody targeting TYRP1. Also known as Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Mouse Monoclonal Antibody. Reactive in Human, Mouse. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Tyrosinase-Related Protein-1 (TYRP-1) (TYRP1), Monoclonal Antibody
Full Product Name
Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Mouse Monoclonal Antibody
Product Gene Name
anti-TYRP1 antibody
Product Synonym Names
5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
TYRP1/807
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
75kDa
OMIM
115501
3D Structure
ModBase 3D Structure for P17643
Cellular Localization
Cytoplasmic
Immunogen
Recombinant full-length human TYRP1 protein
Positive Control
SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.
Applications Tested/Suitable for anti-TYRP1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-TYRP1 antibody
Immunohistochemistry (IHC):
1-2ug/ml 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Immunohistochemistry (IHC) of anti-TYRP1 antibody

Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Monoclonal Antibody (TYRP1/807)
Mouse Anti-TYRP1 Monoclonal Antibody – Cat# MBS439395

SDS-PAGE (SDS) of anti-TYRP1 antibody

SDS-PAGE Analysis of Purified 5,6-dihydroxyindole-2-carboxylic acid oxidase Mouse Monoclonal Antibody (TA99+ TYRP1/807). Confirmation of Purity and Integrity of Antibody.
Mouse Anti-TYRP1 Monoclonal Antibody, SDS-PAGE (SDS) – Cat# MBS439395

Product References and Citations for anti-TYRP1 antibody

Orlow, S.J., et al. 1994. High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. J. Invest. Dermatol. 103: 196-201.

Other Notes

Small volumes of anti-TYRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TYRP1. It may not necessarily be applicable to this product.

NCBI GI #
4507757
NCBI GeneID
7306
NCBI Accession #
NP_000541.1
UniProt Primary Accession #
P17643
UniProt Secondary Accession #
P78468; P78469; Q13721; Q15679
UniProt Related Accession #
P17643
GenBank Nucleotide #
NM_000550.2
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase related protein 1
NCBI Official Symbol
TYRP1
NCBI Official Synonym Symbols
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names
Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
Protein Family
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Gene Name
TYRP1
UniProt Synonym Gene Names
CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1
UniProt Entry Name
TYRP1_HUMAN
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase

NCBI Summary for TYRP1

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

UniProt Comments for TYRP1

TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.

Protein type: Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 1.14.18.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p23

Cellular Component: endosome membrane; melanosome; melanosome membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of melanin biosynthetic process

Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11
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Research Articles on TYRP1

1. Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYRP1 antibody

 Reference Product  PubMed Publications
 DCT antibody  >73 publications with TYRP1 and DCT
 PAX3 antibody  >7 publications with TYRP1 and PAX3
 EDN1 antibody  >3 publications with TYRP1 and EDN1
 TFE3 antibody  >3 publications with TYRP1 and TFE3
 TP53 antibody  >2 publications with TYRP1 and TP53

Pathways associated with anti-TYRP1 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram

Diseases associated with anti-TYRP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >80 publications with TYRP1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >17 publications with TYRP1 and Nervous System Diseases
 Inflammation Antibodies  >10 publications with TYRP1 and Inflammation
 Congenital Abnormalities Antibodies  >9 publications with TYRP1 and Congenital Abnormalities
 Chromosome Aberrations Antibodies  >8 publications with TYRP1 and Chromosome Aberrations
 Breast Neoplasms Antibodies  >7 publications with TYRP1 and Breast Neoplasms
 Oculocutaneous albinism type 3 Antibodies  >7 publications with TYRP1 and Oculocutaneous albinism type 3
 Necrosis Antibodies  >6 publications with TYRP1 and Necrosis
 Lung Neoplasms Antibodies  >4 publications with TYRP1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with TYRP1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-TYRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >225 publications with TYRP1 and Skin
 Eye Antibodies  >79 publications with TYRP1 and Eye
 Brain Antibodies  >15 publications with TYRP1 and Brain
 Embryonic Tissue Antibodies  >14 publications with TYRP1 and Embryonic Tissue
 Ear Antibodies  >6 publications with TYRP1 and Ear
 Kidney Antibodies  >5 publications with TYRP1 and Kidney
 Heart Antibodies  >3 publications with TYRP1 and Heart
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