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CD1B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439494

MBS439494 is an antibody targeting CD1B. Also known as CD1b (T-Cell Surface Glycoprotein) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD1b, Monoclonal Antibody
Full Product Name
CD1b (T-Cell Surface Glycoprotein) Mouse Monoclonal Antibody
Product Gene Name
anti-CD1B antibody
Product Synonym Names
A1 domain; CD1B; Cortical thymocyte antigen CD1B; hTa1 thymocyte antigen; Ly38; T cell surface glycoprotein CD1b; T6/Leu6
Clonality
Monoclonal
Isotype
IgM, kappa
Clone Number
100-1A5
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
The mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
44kDa
OMIM
188360
3D Structure
ModBase 3D Structure for P29016
Cellular Localization
Cell Surface
Immunogen
Stimulated human leukocytes
Hu-Chromosome Location
1q23.1
Positive Control
MOLT4 cells. Human thymus.
Applications Tested/Suitable for anti-CD1B antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Functional Studies
Application Notes for anti-CD1B antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Functional Studies (Order Ab without BSA & Azide)

Product References and Citations for anti-CD1B antibody

Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989. Battistini L, et al. CD1b is expressed in multiple sclerosis lesions. J Neuroimmunol 1996, 67(2):145-151. Khalili-Shirazi A, et al. The distribution of CD1 molecules in inflammatory neuropathy. J Neurol Sci 1998,158(2):154-163. Maher JK and Kronenberg M. The role of CD1 molecules in immune responses to infection. Curr Opin Immunol 1997, 9(4):456-461Blumberg RS et al. Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol Rev 1995, 147:5-29. Salamone MC et al. Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. II. Intracellular detection of CD1 antigens. Dis Markers 1990, 8(5):275-281

Other Notes

Small volumes of anti-CD1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD1B. It may not necessarily be applicable to this product.

NCBI GI #
4502645
NCBI GeneID
910
NCBI Accession #
NP_001755.1
UniProt Primary Accession #
P29016
UniProt Secondary Accession #
Q5TDK9; Q5TDL0; Q9UMM2
UniProt Related Accession #
P29016
GenBank Nucleotide #
NM_001764.2
NCBI Official Full Name
T-cell surface glycoprotein CD1b
NCBI Official Synonym Full Names
CD1b molecule
NCBI Official Symbol
CD1B
NCBI Official Synonym Symbols
R1; CD1; CD1A
UniProt Protein Name
T-cell surface glycoprotein CD1b
UniProt Synonym Protein Names
CD_antigen: CD1b
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD1B
UniProt Entry Name
CD1B_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD1b

NCBI Summary for CD1B

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD1B

CD1B: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cell surface; plasma membrane

Molecular Function: beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; protein binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response
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Research Articles on CD1B

1. the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD1B antibody

 Reference Product  PubMed Publications
 CD83 antibody  >6 publications with CD1B and CD83
 CD209 antibody  >3 publications with CD1B and CD209
 KIRREL antibody  >1 publications with CD1B and KIRREL
 PSAP antibody  >1 publications with CD1B and PSAP
 B2M antibody  >1 publications with CD1B and B2M

Pathways associated with anti-CD1B antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-CD1B antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >16 publications with CD1B and Leukemia
 Inflammation Antibodies  >12 publications with CD1B and Inflammation
 Necrosis Antibodies  >11 publications with CD1B and Necrosis
 Lymphoma Antibodies  >11 publications with CD1B and Lymphoma
 Dermatitis Antibodies  >9 publications with CD1B and Dermatitis
 Skin Neoplasms Antibodies  >7 publications with CD1B and Skin Neoplasms
 Lung Diseases Antibodies  >7 publications with CD1B and Lung Diseases
 Lymphoma, Non-Hodgkin Antibodies  >5 publications with CD1B and Lymphoma, Non-Hodgkin
 Lung Diseases, Interstitial Antibodies  >4 publications with CD1B and Lung Diseases, Interstitial
 Neurologic Manifestations Antibodies  >4 publications with CD1B and Neurologic Manifestations

Organs/Tissues associated with anti-CD1B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >219 publications with CD1B and Blood
 Thymus Antibodies  >21 publications with CD1B and Thymus
 Kidney Antibodies  >6 publications with CD1B and Kidney
 Heart Antibodies  >5 publications with CD1B and Heart
 Lung Antibodies  >5 publications with CD1B and Lung
 Eye Antibodies  >1 publications with CD1B and Eye
 Pharynx Antibodies  >1 publications with CD1B and Pharynx
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