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Moesin (MSN) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439525

MBS439525 is an antibody targeting MSN. Also known as Moesin Mouse Monoclonal Antibody. Reactive in Human.Does not react with Rat. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Moesin (MSN), Monoclonal Antibody
Full Product Name
Moesin Mouse Monoclonal Antibody
Product Gene Name
Product Synonym Names
Membrane-organizing extension spike protein; Moesin/anaplastic lymphoma kinase fusion protein; MSN/ALK fusion
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
MSN/492
Host
Mouse
Species Reactivity
Human.
Does not react with Rat
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes 78kDa moesin protein. Moesin, a member of the talin-4.1 superfamily, is a linking protein of the sub-membranous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
78kDa
OMIM
309845
3D Structure
ModBase 3D Structure for P26038
Cellular Localization
Cytoplasmic & Cell Surface
Immunogen
Recombinant full-length human Moesin protein
Hu-Chromosome Location
Xq11.1
Positive Control
HT-29, CH3LC, or HUVEC cells. Uterus, Placenta, Tonsil, Melanoma, Testicular Carcinoma.
Applications Tested/Suitable for anti-MSN antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
Application Notes for anti-MSN antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-MSN antibody

Formalin-fixed, paraffin-embedded human Melanoma stained with Moesin Monoclonal Antibody (MSN/492)
Mouse Anti-MSN Monoclonal Antibody – Cat# MBS439525

Immunohistochemistry (IHC) of anti-MSN antibody

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Moesin Monoclonal Antibody (MSN/492)
Mouse Anti-MSN Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS439525

Immunohistochemistry (IHC) of anti-MSN antibody

Formalin-fixed, paraffin-embedded human Placenta stained with Moesin Monoclonal Antibody (MSN/492)
Mouse Anti-MSN Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS439525

Product References and Citations for anti-MSN antibody

Schwartz-Albiez R et. al., European Journal Cell Biology, 1995; 67:189-198. Lankes W et. al., Biochem Journal, 1988; 251:831-842.

Other Notes

Small volumes of anti-MSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MSN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
moesin
NCBI Official Synonym Full Names
moesin
NCBI Official Symbol
MSN
NCBI Official Synonym Symbols
HEL70
UniProt Protein Name
Moesin
UniProt Synonym Protein Names
Membrane-organizing extension spike protein
Protein Family
UniProt Gene Name
MSN
UniProt Entry Name
MOES_HUMAN
NCBI Protein Information
moesin

NCBI Summary for MSN

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
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UniProt Comments for MSN

Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-MSN antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >236 publications with MSN and Skin
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