Mouse Anti-THY1 Monoclonal Antibody – Cat# MBS439589

SDS-PAGE Analysis Purified CD90 Mouse Monoclonal antibody (AF-9). Confirmation of Purity and Integrity of Antibody.

CD90 / Thy1 (THY1) Antibody – Mouse Monoclonal

Name: THY1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439589
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439589

MBS439589 is an antibody targeting THY1. Also known as CD90 / Thy1 (Stromal / Mesenchymal Marker) Mouse Monoclonal Antibody. Reactive in Human, Cow. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD90 / Thy1, Monoclonal Antibody

Full Product Name

CD90 / Thy1 (Stromal / Mesenchymal Marker) Mouse Monoclonal Antibody

Product Gene Name

anti-THY1 antibody

Product Synonym Names

CD90; Theta antigen; Thy 1 cell surface antigen; Thy 1 membrane glycoprotein; Thy 1.2; Thy-1 antigen; Thy-1 membrane glycoprotein; Thy1; Thy1 T cell antigen; Thy1.1; Thy1.2; Thymus cell antigen 1, theta

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

AF-9

Host

Mouse

Species Reactivity

Human, Cow

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Recognizes a protein of 18-35kDa, identified as CD90 (also known as Thy1). CD90 is a member of the immunoglobulin superfamily. It may contribute to inhibition of proliferation/differentiation of hematopoietic stem cells and neuron memory formation in the CNS. It consists of a single Ig domain (112 amino acids; 25-35 kDa) inserted into the cell membrane via a GPI anchor. Expressed by hematopoietic stem cells and neurons in all species studied. Its highly expressed in connective tissue and various fibroblast and stromal cell lines, expressed on all thymocytes and peripheral T cells in mice, but in humans expressed only on small % fetal thymocytes, 10-40% of CD34+ cells in bone marrow, and <1% of CD3+CD4+ lymphocytes in peripheral circulation. It is also expressed by human lymph node HEV endothelium but not other endothelia. Lastly, it is expressed by a limited number of lymphoblastoid and leukemic cell lines

Preparation and Storage

Antibody with azide - store at 2 to 8°C. Non-hazardous. No MSDS required.

Molecular Weight

18-35kDa

OMIM

188230

3D Structure

ModBase 3D Structure for P04216

Cellular Localization

Cell Surface

Immunogen

Human T-lymphoma cells

Hu-Chromosome Location

11q23.3

Positive Control

IMR-32, CCRF-CEM or MOLT-4 cells. Human uterus.

Applications Tested/Suitable for anti-THY1 antibody

Flow Cytometry (FC), Immunofluorescence (IF)

Application Notes for anti-THY1 antibody

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.

Product References and Citations for anti-THY1 antibody

Beissert S et al. Impaired cutaneous immune responses in Thy-1-deficient mice. J Immunol 1998, 161(10):5296-302 Williams, A.F., and J. Gagnon. 1982. Neuronal cell Thy-1 glycoprotein: Homology with immunoglobulin. Science 216: 696 - 703 Fujita N et al. Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Exp Cell Res 1997, 232(2):400-406 Kroczek, R.A., K.C. Gunter, R.N. Germain, and E.M. Shevach. 1986. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature 322: 181 - 184

Other Notes

Small volumes of anti-THY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for THY1. It may not necessarily be applicable to this product.

NCBI GI #

902967471

NCBI GeneID

7070

NCBI Accession #

NP_001298089.1

UniProt Primary Accession #

P04216

UniProt Secondary Accession #

Q16008; Q9NSP1

UniProt Related Accession #

P04216

GenBank Nucleotide #

NM_001311160.1

NCBI Official Full Name

thy-1 membrane glycoprotein preproprotein

NCBI Official Synonym Full Names

Thy-1 cell surface antigen

NCBI Official Symbol

THY1

NCBI Official Synonym Symbols

CD90; CDw90

UniProt Protein Name

Thy-1 membrane glycoprotein

UniProt Synonym Protein Names

CDw90; Thy-1 antigen; CD_antigen: CD90

Protein Family

Thy-1 membrane glycoprotein

UniProt Gene Name

THY1

UniProt Entry Name

THY1_HUMAN

NCBI Protein Information

thy-1 membrane glycoprotein

NCBI Summary for THY1

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

UniProt Comments for THY1

THY1: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: anchored to external side of plasma membrane; apical plasma membrane; dendrite; endoplasmic reticulum; external side of plasma membrane; focal adhesion; growth cone; integral to plasma membrane; lipid raft; myelin sheath; plasma membrane

Molecular Function: GTPase activator activity; integrin binding; protein binding; protein kinase binding

Biological Process: angiogenesis; cell-cell adhesion; cytoskeleton organization and biogenesis; focal adhesion formation; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of protein kinase activity; negative regulation of T cell receptor signaling pathway; positive regulation of GTPase activity; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of T cell activation; retinal cone cell development; T cell receptor signaling pathway

Research Articles on THY1

1. CD105+/CD90+ subpopulation from breast cancer MDA-MB-231 cells possesses "mesenchymal stem cell-like" characteristics, and its high migratory ability might be associated with epithelial-mesenchymal transformation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-THY1 antibody

Reference Product	PubMed Publications
ITGB2 antibody	>1 publications with THY1 and ITGB2
STAT6 antibody	>1 publications with THY1 and STAT6
ITGAM antibody	>1 publications with THY1 and ITGAM

Pathways associated with anti-THY1 antibody

Products by Pathway	Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-THY1 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>254 publications with THY1 and Disease Models, Animal
Kidney Diseases Antibodies	>201 publications with THY1 and Kidney Diseases
Nervous System Diseases Antibodies	>181 publications with THY1 and Nervous System Diseases
Inflammation Antibodies	>90 publications with THY1 and Inflammation
Proteinuria Antibodies	>82 publications with THY1 and Proteinuria
Neoplasms, Experimental Antibodies	>68 publications with THY1 and Neoplasms, Experimental
Fibrosis Antibodies	>46 publications with THY1 and Fibrosis
Necrosis Antibodies	>43 publications with THY1 and Necrosis
Nerve Degeneration Antibodies	>38 publications with THY1 and Nerve Degeneration
Liver Diseases Antibodies	>35 publications with THY1 and Liver Diseases

Organs/Tissues associated with anti-THY1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>686 publications with THY1 and Blood
Spleen Antibodies	>281 publications with THY1 and Spleen
Brain Antibodies	>224 publications with THY1 and Brain
Kidney Antibodies	>220 publications with THY1 and Kidney
Bone Antibodies	>220 publications with THY1 and Bone
Bone Marrow Antibodies	>208 publications with THY1 and Bone Marrow
Nerve Antibodies	>157 publications with THY1 and Nerve
Thymus Antibodies	>135 publications with THY1 and Thymus
Eye Antibodies	>117 publications with THY1 and Eye
Liver Antibodies	>112 publications with THY1 and Liver