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CD71 / Transferrin Receptor (TFRC) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439633

MBS439633 is an antibody targeting TFRC. Also known as CD71 / Transferrin Receptor (TFRC) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD71 / Transferrin Receptor (TFRC), Monoclonal Antibody
Full Product Name
CD71 / Transferrin Receptor (TFRC) Mouse Monoclonal Antibody
Product Gene Name
anti-TFRC antibody
Product Synonym Names
Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
TFRC/1059
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
85-95kDa (monomer); 190kDa (dimer)
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Cellular Localization
Cell Surface
Immunogen
Recombinant human TFRC protein
Hu-Chromosome Location
3q29
Positive Control
CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.
Applications Tested/Suitable for anti-TFRC antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-TFRC antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)

Flow Cytometry (FC/FACS) of anti-TFRC antibody

Flow Cytometry of human CD71 on Jurkat Cells. Black: Cells alone; Grey: Isotype Control; Green: AF488-labeled CD71 Monoclonal Antibody (TFRC/1059).
Mouse Anti-TFRC Monoclonal Antibody – Cat# MBS439633

Product References and Citations for anti-TFRC antibody

Van de Rijna M, Geurts van Kessel AHM, Kroezen V, van Agthoven AJ, Verstijnen K, Terhorst C, Hilgers J: Cytogenet Cell Genet 1983;36:525-531. Oudermans et al. Cancer, 1986; 58:1252. K. Moolenaar et al. Cancer research 50,1102-1106, 1990

Other Notes

Small volumes of anti-TFRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
GenBank Nucleotide #
NM_001128148.2
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
Protein Family
Transferrin receptor protein
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for TFRC

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for TFRC

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity

Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport
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Research Articles on TFRC

1. siRNA targeted delivery using transferrin-coupled lipoplexes specifically sensitizes CD71 high expressing malignant cells to antibody-mediated complement attack

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TFRC antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with anti-TFRC antibody

 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >35 publications with TFRC and Iron Metabolism Disorders
 Anemia Antibodies  >25 publications with TFRC and Anemia
 Disease Models, Animal Antibodies  >20 publications with TFRC and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >14 publications with TFRC and Anemia, Iron-Deficiency
 Inflammation Antibodies  >13 publications with TFRC and Inflammation
 Lung Neoplasms Antibodies  >10 publications with TFRC and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with TFRC and Breast Neoplasms
 Liver Diseases Antibodies  >9 publications with TFRC and Liver Diseases
 Cardiovascular Diseases Antibodies  >7 publications with TFRC and Cardiovascular Diseases
 Kidney Diseases Antibodies  >7 publications with TFRC and Kidney Diseases

Organs/Tissues associated with anti-TFRC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >61 publications with TFRC and Blood
 Liver Antibodies  >31 publications with TFRC and Liver
 Brain Antibodies  >30 publications with TFRC and Brain
 Bone Antibodies  >16 publications with TFRC and Bone
 Lung Antibodies  >15 publications with TFRC and Lung
 Intestine Antibodies  >15 publications with TFRC and Intestine
 Kidney Antibodies  >12 publications with TFRC and Kidney
 Skin Antibodies  >9 publications with TFRC and Skin
 Embryonic Tissue Antibodies  >8 publications with TFRC and Embryonic Tissue
 Vascular Antibodies  >8 publications with TFRC and Vascular
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