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PD1 / PDCD1 /CD279 (Programmed Cell Death 1) (PDCD1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439735

MBS439735 is an antibody targeting PDCD1. Also known as PD1 / PDCD1 /CD279 (Programmed Cell Death 1) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PD1 / PDCD1 /CD279 (Programmed Cell Death 1), Monoclonal Antibody
Full Product Name
PD1 / PDCD1 /CD279 (Programmed Cell Death 1) Mouse Monoclonal Antibody
Product Gene Name
anti-PDCD1 antibody
Product Synonym Names
CD279; hPD-1; hSLE1; PD1; PDCD1; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
PDCD1/922
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
55kDa
OMIM
109100
3D Structure
ModBase 3D Structure for Q15116
Cellular Localization
Cell Surface & Cytoplasmic
Immunogen
Recombinant full-length human PDCD1 protein
Hu-Chromosome Location
2q37.3
Positive Control
TY cells or Tonsil.
Applications Tested/Suitable for anti-PDCD1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-PDCD1 antibody
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)

Immunohistochemistry (IHC) of anti-PDCD1 antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Monoclonal Antibody (PDCD1/922).
Mouse Anti-PDCD1 Monoclonal Antibody – Cat# MBS439735

Immunohistochemistry (IHC) of anti-PDCD1 antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Monoclonal Antibody (PDCD1/922).
Mouse Anti-PDCD1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS439735

Product References and Citations for anti-PDCD1 antibody

Ishida, Y., et al. 1992. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11: 3887-3895.

Other Notes

Small volumes of anti-PDCD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDCD1. It may not necessarily be applicable to this product.

NCBI GI #
167857792
NCBI GeneID
5133
NCBI Accession #
NP_005009.2
UniProt Primary Accession #
Q15116
UniProt Secondary Accession #
O00517; Q8IX89
UniProt Related Accession #
Q15116
GenBank Nucleotide #
NM_005018.2
NCBI Official Full Name
programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
PDCD1
NCBI Official Synonym Symbols
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
UniProt Protein Name
Programmed cell death protein 1
UniProt Synonym Protein Names
CD_antigen: CD279
Protein Family
Programmed cell death protein
UniProt Gene Name
PDCD1
UniProt Synonym Gene Names
PD1; Protein PD-1; hPD-1
UniProt Entry Name
PDCD1_HUMAN
NCBI Protein Information
programmed cell death protein 1

NCBI Summary for PDCD1

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
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UniProt Comments for PDCD1

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: plasma membrane

Molecular Function: protein binding; signal transducer activity

Biological Process: humoral immune response; multicellular organismal development; T cell costimulation

Disease: Systemic Lupus Erythematosus
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Research Articles on PDCD1

1. genetic mechanism of tumor immune escape caused by structural variations commonly disrupting the 3' region of the PD-L1 gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDCD1 antibody

 Reference Product  PubMed Publications
 CD274 antibody  >520 publications with PDCD1 and CD274
 PDCD1LG2 antibody  >120 publications with PDCD1 and PDCD1LG2
 PTPN11 antibody  >7 publications with PDCD1 and PTPN11
 LCK antibody  >4 publications with PDCD1 and LCK
 HLA-DRB1 antibody  >3 publications with PDCD1 and HLA-DRB1
 CD8A antibody  >3 publications with PDCD1 and CD8A
 CD3E antibody  >2 publications with PDCD1 and CD3E
 CSK antibody  >1 publications with PDCD1 and CSK

Pathways associated with anti-PDCD1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-PDCD1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >168 publications with PDCD1 and Liver Diseases
 Melanoma Antibodies  >154 publications with PDCD1 and Melanoma
 Inflammation Antibodies  >153 publications with PDCD1 and Inflammation
 Lung Diseases Antibodies  >110 publications with PDCD1 and Lung Diseases
 Lung Neoplasms Antibodies  >95 publications with PDCD1 and Lung Neoplasms
 Necrosis Antibodies  >93 publications with PDCD1 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >81 publications with PDCD1 and Lupus Erythematosus, Systemic
 Adenocarcinoma Antibodies  >72 publications with PDCD1 and Adenocarcinoma
 Kidney Diseases Antibodies  >47 publications with PDCD1 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >36 publications with PDCD1 and Neoplasm Metastasis

Organs/Tissues associated with anti-PDCD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1202 publications with PDCD1 and Blood
 Kidney Antibodies  >56 publications with PDCD1 and Kidney
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