Mouse Anti-MYADM Monoclonal Antibody – Cat# MBS439745

Formalin-fixed, paraffin-embedded human Tonsil stained with MYDAM Monoclonal Antibody (MYADM/971).

Myeloid-Associated Differentiation Marker (MYADM) Antibody – Mouse Monoclonal

Name: MYADM Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439745
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439745

MBS439745 is an antibody targeting MYADM. Also known as Myeloid-Associated Differentiation Marker (MYADM) Mouse Monoclonal Antibody. Reactive in Human, Macaque Monkey. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Myeloid-Associated Differentiation Marker (MYADM), Monoclonal Antibody

Full Product Name

Myeloid-Associated Differentiation Marker (MYADM) Mouse Monoclonal Antibody

Product Gene Name

anti-MYADM antibody

Product Synonym Names

MYADM; myeloid associated differentiation marker; Myeloid upregulated protein; Protein SB135

Clonality

Monoclonal

Isotype

IgG1

Clone Number

MYADM/971

Host

Mouse

Species Reactivity

Human, Macaque Monkey

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Recognizes a myeloid associated differentiation antigen in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell type in human tissues. Markers of myeloid cells are useful in the identification of different levels of cellular differentiation. It reacts with early precursor and mature forms of human and monkey myeloid cells. This MAb is useful for the detection of myeloid leukemias and granulocytic sarcomas. It can be used as a marker of granulocytes in normal tissues or inflammatory processes.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

35,274 Da

OMIM

609959

3D Structure

ModBase 3D Structure for Q96S97

Cellular Localization

Cytoplasmic

Immunogen

Recombinant human MYADM protein

Hu-Chromosome Location

19q13.42

Positive Control

HL60 cells. Tonsil or lymph node

Applications Tested/Suitable for anti-MYADM antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-MYADM antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-MYADM antibody

Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Wang Q, et al. Life Sci, 2007 Jan 9. PMID 17097684 Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. Cui W, et al. Mol Biol Rep, 2001. PMID 12075932 MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Aranda JF, et al. Mol Biol Cell, 2013 Feb. PMID 23264465 MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. Aranda JF, et al. Mol Biol Cell, 2011 Apr 15. PMID 21325632 Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multi-potent progenitor cells and up-regulated during myeloid differentiation. Pettersson M, et al. J Leukoc Biol, 2000 Mar. PMID 1073310

Other Notes

Small volumes of anti-MYADM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYADM. It may not necessarily be applicable to this product.

NCBI GI #

66932923

NCBI GeneID

91663

NCBI Accession #

NP_001018654.1

UniProt Primary Accession #

Q96S97

UniProt Secondary Accession #

Q542Z1; Q7Z507; Q8N9R4; Q96CS6; Q96SK9; B2RE58

UniProt Related Accession #

Q96S97

GenBank Nucleotide #

NM_001020818.2

NCBI Official Full Name

myeloid-associated differentiation marker

NCBI Official Synonym Full Names

myeloid associated differentiation marker

NCBI Official Symbol

MYADM

NCBI Official Synonym Symbols

SB135

UniProt Protein Name

Myeloid-associated differentiation marker

UniProt Synonym Protein Names

Protein SB135

Protein Family

Myeloid-associated differentiation marker

UniProt Gene Name

MYADM

UniProt Entry Name

MYADM_HUMAN

NCBI Protein Information

myeloid-associated differentiation marker

UniProt Comments for MYADM

MYADM: Belongs to the MAL family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cortical actin cytoskeleton; intercellular junction; lipid raft; plasma membrane; ruffle

Biological Process: intercellular junction maintenance; lipid raft organization and biogenesis; negative regulation of actin filament polymerization; negative regulation of heterotypic cell-cell adhesion; negative regulation of protein amino acid phosphorylation; positive regulation of cell migration

Research Articles on MYADM

1. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-MYADM antibody

Disease Name	Pubmed Publications
Hypertension Antibodies	>2 publications with MYADM and Hypertension
Inflammation Antibodies	>1 publications with MYADM and Inflammation
Necrosis Antibodies	>1 publications with MYADM and Necrosis

Organs/Tissues associated with anti-MYADM antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with MYADM and Blood
Bone Marrow Antibodies	>3 publications with MYADM and Bone Marrow
Bone Antibodies	>3 publications with MYADM and Bone
Kidney Antibodies	>2 publications with MYADM and Kidney
Lung Antibodies	>2 publications with MYADM and Lung
Muscle Antibodies	>1 publications with MYADM and Muscle
Thymus Antibodies	>1 publications with MYADM and Thymus
Heart Antibodies	>1 publications with MYADM and Heart
Vascular Antibodies	>1 publications with MYADM and Vascular
Skin Antibodies	>1 publications with MYADM and Skin