Mouse Anti-CTNNA1 Monoclonal Antibody – Cat# MBS439891

Western Blot of A431 and MCF-7 Cell Lysates using Catenin, alpha-1 Mouse Monoclonal Antibody (1G5)

Catenin, Alpha-1 (CTNNA1) Antibody – Mouse Monoclonal

Name: CTNNA1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439891
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439891

MBS439891 is an antibody targeting CTNNA1. Also known as Catenin, alpha-1 (CTNNA1). Reactive in Human. Others not known.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Catenin, alpha-1 (CTNNA1), Monoclonal Antibody

Full Product Name

Catenin, alpha-1 (CTNNA1)

Product Gene Name

anti-CTNNA1 antibody

Product Synonym Names

Alpha E-catenin; Cadherin-associated protein; CAP102; Catenin alpha-1; CTNNA1; Renal carcinoma antigen NY-REN-13

Clonality

Monoclonal

Isotype

IgG1

Clone Number

1G5

Host

Mouse

Species Reactivity

Human. Others not known.

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-catenin forms a heterodimer with beta-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

102kDa

3D Structure

ModBase 3D Structure for P35221

Immunogen

Human alpha catenin fusion protein

Cellular Localization

Cell Surface

Hu-chromosome Location

5q31.2

Positive Control

HeLa, A431 or MCF-7 Cells

Applications Tested/Suitable for anti-CTNNA1 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

Application Notes for anti-CTNNA1 antibody

FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
WB: 0.5-1.0ug/ml

Product References and Citations for anti-CTNNA1 antibody

Johnson, KR; Lewis, JE; Li, D; Wahl, J; Soler, AP; Knudsen, KA; Wheelock, MJ. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252-60. Nieman, MT; Kim, JB; Johnson, KR; Wheelock, MJ. Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Science 1999, 112: 1621-3.

Other Notes

Small volumes of anti-CTNNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNA1. It may not necessarily be applicable to this product.

NCBI GI #

594140506

NCBI GeneID

1495

NCBI Accession #

NP_001277236.1

UniProt Primary Accession #

P35221

UniProt Secondary Accession #

Q12795; Q8N1C0

UniProt Related Accession #

P35221

GenBank Nucleotide #

NM_001290307.2

NCBI Official Full Name

catenin alpha-1 isoform 2

NCBI Official Synonym Full Names

catenin alpha 1

NCBI Official Symbol

CTNNA1

NCBI Official Synonym Symbols

MDPT2; CAP102

UniProt Protein Name

Catenin alpha-1

UniProt Synonym Protein Names

Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13

Protein Family

Catenin

UniProt Gene Name

CTNNA1

NCBI Protein Information

catenin alpha-1

NCBI Summary for CTNNA1

This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]

UniProt Comments for CTNNA1

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Research Articles on CTNNA1

1. The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTNNA1 antibody

Reference Product	PubMed Publications
CTNNB1 antibody	>402 publications with CTNNA1 and CTNNB1
JUP antibody	>86 publications with CTNNA1 and JUP
TJP1 antibody	>19 publications with CTNNA1 and TJP1
CDH1 antibody	>9 publications with CTNNA1 and CDH1
CDH2 antibody	>3 publications with CTNNA1 and CDH2
VCL antibody	>2 publications with CTNNA1 and VCL
CTNND1 antibody	>1 publications with CTNNA1 and CTNND1
CDH5 antibody	>1 publications with CTNNA1 and CDH5

Pathways associated with anti-CTNNA1 antibody

Products by Pathway	Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Arf6 Trafficking Events Pathway antibodies	Arf6 Trafficking Events Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram

Diseases associated with anti-CTNNA1 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>213 publications with CTNNA1 and Carcinoma
Adenocarcinoma Antibodies	>94 publications with CTNNA1 and Adenocarcinoma
Breast Neoplasms Antibodies	>48 publications with CTNNA1 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>31 publications with CTNNA1 and Carcinoma, Squamous Cell
Liver Neoplasms Antibodies	>27 publications with CTNNA1 and Liver Neoplasms
Lung Neoplasms Antibodies	>23 publications with CTNNA1 and Lung Neoplasms
Lung Diseases Antibodies	>22 publications with CTNNA1 and Lung Diseases
Neoplasms, Experimental Antibodies	>18 publications with CTNNA1 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>17 publications with CTNNA1 and Cell Transformation, Neoplastic
Kidney Diseases Antibodies	>16 publications with CTNNA1 and Kidney Diseases

Organs/Tissues associated with anti-CTNNA1 antibody

Organ/Tissue Name	Pubmed Publications
Lymph Antibodies	>53 publications with CTNNA1 and Lymph
Lymph Node Antibodies	>53 publications with CTNNA1 and Lymph Node
Liver Antibodies	>36 publications with CTNNA1 and Liver
Vascular Antibodies	>29 publications with CTNNA1 and Vascular
Prostate Antibodies	>29 publications with CTNNA1 and Prostate
Stomach Antibodies	>28 publications with CTNNA1 and Stomach
Embryonic Tissue Antibodies	>27 publications with CTNNA1 and Embryonic Tissue
Kidney Antibodies	>25 publications with CTNNA1 and Kidney
Blood Antibodies	>25 publications with CTNNA1 and Blood
Lung Antibodies	>25 publications with CTNNA1 and Lung