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Ferritin, Light Chain (FTL) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439983

MBS439983 is an antibody targeting FTL. Also known as Ferritin, Light Chain (FTL) (Microglia Marker). Reactive in Human. Others not known.. Host: Rabbit. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ferritin, Light Chain (FTL), Monoclonal Antibody
Full Product Name
Ferritin, Light Chain (FTL) (Microglia Marker)
Product Gene Name
anti-FTL antibody
Product Synonym Names
Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; FTL; LFTD; NBIA3
Clonality
Monoclonal
Isotype
IgG
Clone Number
FTL/2338R
Host
Rabbit
Species Reactivity
Human. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
19-25kDa
3D Structure
ModBase 3D Structure for P02792
Immunogen
Recombinant fragment of human FTL protein (around aa 38-165)
Cellular Localization
Cytoplasmic
Hu-chromosome Location
19q13.33
Positive Control
HepG2, HeLa, HL-60 or 293T cells. Pancreas, Liver, Cerebellum or Testis.
Applications Tested/Suitable for anti-FTL antibody
Immunohistochemistry (IHC) Formalin
Application Notes for anti-FTL antibody
IHC-F: 0.5-1.0ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-FTL antibody

Formalin-fixed, paraffin-embedded Human Breast Carcinoma stained with Ferritin, Light Chain Rabbit Recombinant Monoclonal Antibody (FTL/2338R).
Rabbit Anti-FTL Monoclonal Antibody – Cat# MBS439983

SDS-Page of anti-FTL antibody

SDS-PAGE Analysis of Purified Ferritin, Light Chain Rabbit Recombinant Monoclonal Antibody (FTL/2338R).
Rabbit Anti-FTL Monoclonal Antibody, SDS-Page – Cat# MBS439983

Product References and Citations for anti-FTL antibody

Y.Kaneko, T.Kitamoto, J.Tateishi, K.Yamaguchi. Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathologica. 1989, Volume 79; 129-136.

Other Notes

Small volumes of anti-FTL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.

NCBI GI #
20149498
NCBI GeneID
2512
NCBI Accession #
NP_000137.2
UniProt Primary Accession #
P02792
UniProt Secondary Accession #
Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9
UniProt Related Accession #
P02792
GenBank Nucleotide #
NM_000146.3
NCBI Official Full Name
ferritin light chain
NCBI Official Synonym Full Names
ferritin light chain
NCBI Official Symbol
FTL
NCBI Official Synonym Symbols
LFTD; NBIA3
UniProt Protein Name
Ferritin light chain
Protein Family
Ferritin
UniProt Gene Name
FTL
UniProt Synonym Gene Names
Ferritin L subunit
NCBI Protein Information
ferritin light chain

NCBI Summary for FTL

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
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UniProt Comments for FTL

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney ().

Research Articles on FTL

1. Determining serum ferritin is a convenient and nonexpensive method to determine the outcome of the treatment of the cases with oral squamous cell carcinoma . Its potential as prognostic marker could not be overlooked

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FTL antibody

 Reference Product  PubMed Publications
 FTH1 antibody  >12 publications with FTL and FTH1
 HSPA8 antibody  >1 publications with FTL and HSPA8
 FECH antibody  >1 publications with FTL and FECH

Pathways associated with anti-FTL antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-FTL antibody

 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >43 publications with FTL and Iron Metabolism Disorders
 Nervous System Diseases Antibodies  >38 publications with FTL and Nervous System Diseases
 Brain Diseases Antibodies  >30 publications with FTL and Brain Diseases
 Neuroferritinopathy Antibodies  >28 publications with FTL and Neuroferritinopathy
 Inflammation Antibodies  >13 publications with FTL and Inflammation
 Disease Models, Animal Antibodies  >11 publications with FTL and Disease Models, Animal
 Hyperferritinemia, hereditary, with congenital cataracts Antibodies  >10 publications with FTL and Hyperferritinemia, hereditary, with congenital cataracts
 Cardiovascular Diseases Antibodies  >8 publications with FTL and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >8 publications with FTL and Breast Neoplasms
 Heredodegenerative Disorders, Nervous System Antibodies  >7 publications with FTL and Heredodegenerative Disorders, Nervous System

Organs/Tissues associated with anti-FTL antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with FTL and Brain
 Blood Antibodies  >55 publications with FTL and Blood
 Liver Antibodies  >20 publications with FTL and Liver
 Nerve Antibodies  >16 publications with FTL and Nerve
 Eye Antibodies  >14 publications with FTL and Eye
 Heart Antibodies  >12 publications with FTL and Heart
 Vascular Antibodies  >10 publications with FTL and Vascular
 Muscle Antibodies  >9 publications with FTL and Muscle
 Lung Antibodies  >9 publications with FTL and Lung
 Bone Antibodies  >8 publications with FTL and Bone
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