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DBC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS440073

Representational difference analysis (RDA) was the technique used to map a region on human chromosome 8p21 that contained a homozygous deletion several of the breast cancer specimens studied (1). The mapping of this region led to the identification of a gene… More details

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Product Overview

Online Datasheet in PDF
Product Name
DBC2, Polyclonal Antibody
Full Product Name
DBC2 (N15) Antibody
Product Gene Name
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, rat, human
Form/Format
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
Concentration
0.200 mg/ml (lot specific)
Specificity
Mouse, rat, and human DBC2
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
Antibody/Peptide Pairs
DBC2 peptide (MBS443070) is used for blocking the activity of DBC2 antibody (MBS440073)
Molecular Weight
83,469 Da
OMIM
607352
3D Structure
ModBase 3D Structure for Q9BYZ6
Origin
DBC2 (N15) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminal domain of human DBC2.
Immunogen
Synthetic peptide mapping to the amino terminal domain of human DBC2
Applications Tested/Suitable for anti-DBC2 antibody
Western Blot (WB)

Product References and Citations for anti-DBC2 antibody

1.) Siripurapu V, Meth J, Kobayashi N, Hamaguchi M. 2005. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. J Mol Biol. Feb 11;346(1):83-9.2.) Yoshihara T, Collado D, Hamaguchi M. 2007, Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function. Biochem Biophys Res Commun. Jul 13;358(4):1076-9.

1. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH. 2002. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. PNAS USA 99(21):13647-13652.

Other Notes

Small volumes of anti-DBC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DBC2 purchase

MBS440073 is an antibody targeting DBC2. Also known as DBC2 (N15) Antibody. Reactive in Mouse, rat, human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DBC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
DBC2
NCBI Official Synonym Full Names
Rho-related BTB domain containing 2
NCBI Official Symbol
RHOBTB2
NCBI Official Synonym Symbols
DBC2
UniProt Protein Name
Rho-related BTB domain-containing protein 2
UniProt Synonym Protein Names
Deleted in breast cancer 2 gene protein; p83
UniProt Gene Name
RHOBTB2
UniProt Synonym Gene Names
DBC2; KIAA0717
UniProt Entry Name
RHBT2_HUMAN
NCBI Protein Information
rho-related BTB domain-containing protein 2; deleted in breast cancer 2 gene protein; p83

NCBI Summary for DBC2

The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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UniProt Comments for DBC2

RHOBTB2: is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: G protein; G protein, monomeric, Rho; G protein, monomeric

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: plasma membrane; cytosol

Molecular Function: GTP binding

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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