AP-2alphabeta Antibody – Mouse Monoclonal

The AP-2 transcription factor exists in three isoforms, alpha, beta, and gamma that have proven to be essential for gene expression associated with ectodermal development (1,2). The AP-2 isoforms have also been shown to compose the OB2-1 transcription factor (3,4). OB2-1 has been shown to upregulate c-erbB-2 (Neu), which is overexpressed in 25-30% of breast cancers through increased transcription and amplification of the gene (3). All three AP-2 isoforms are capable of binding to the c-erbB-2 promoter as homo or heterodimers (3). One study has found that AP-2alpha and AP-2gamma are expressed at elevated levels in the majority of c-erbB-2 overexpressing mammary tumor lines they examined (3).

1. Oyama N, Takahashi H, Tojo M, Iwatsuki K, Iizuka H, Nakamura K, Homma Y, Kaneko F. 2002. Different properties of three isoforms (alpha, beta, and gamma) of transcription factor AP-2 in the expression of human keratinocytes. Arch Dermatol Res. 294(6):273-280.2. Hilger-Eversheim K, Moser M, Schorle H, Buettner R. 2000. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell cycle control. Gene 260(1-2):1-12.3. Bosher JM, Totty NF, Hsuan JJ, Williams T, Hurst HC. 1996. A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene 13(8): 1701-1707.4. Bosher JM, Williams T, Hurst HC. 1995. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci USA 92(3): 744-747.

Small volumes of anti-AP-2alphabeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS440097 is an antibody targeting AP-2alphabeta. Also known as AP-2alphabeta (A6/2/2) Antibody. Reactive in Human. Host: Mouse.