Keratocan (KERA) Antibody – Mouse Monoclonal

Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Tissue specificity: Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen. Ref.4

Post-translational modification: Binds keratan sulfate chains

By similarity.

Involvement in disease: The autosomal recessive cornea plana 2 (CNA2) [MIM:217300]: In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.6

Sequence similarities: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.Contains 10 LRR (leucine-rich) repeats.Contains 1 LRRNT domain.