Human CCL7 Active Protein – Cat# MBS444006

CCL7 Human Active Protein

Name: CCL7 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS444006
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS444006

Monocyte chemotactic protein 3 (MCP-3/CCL7) is secreted by monocytes and certain tumor cell lines. It is a chemoattractant for monocytes and other leukocytes. MCP-3 binds and signals through several chemokine receptors including CCR1, CCR2, CCR3, and appears… More details

$220 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCL7, Active Protein

Full Product Name

Human CCL7 (MCP-3)

Product Gene Name

CCL7 active protein

Product Synonym Names

CCL7 (MCP-3) Biotin

Sequence

QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL

Host

E Coli derived

Form/Format

Lyophilized

Purity/Purification

> 97% by SDS PAGE

Preparation and Storage

Spin sample prior to reconstitution. Avoid repeated freeze-thaw cycles
12 months from date of receipt, -20 to -70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, -20 to -70 degree C under sterile conditions after reconstitution.

Matching Pairs

Unconjugated Antibody: CCL7 (MBS444005)
Biotin Conjugated Antibody: CCL7 (MBS444006)

Molecular Weight

Actual Molecular Mass: Mass spec data confirmed the expected mass of 8.956 kDa
Predicted Molecular Mass: 8.956 kDa

Sequence Positions

24-99

OMIM

158106

3D Structure

ModBase 3D Structure for P80098

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Spin sample prior to reconstitution. Recommended at 100mug/mL in sterile water

Carrier Protein

None

Activity

EC50 = 0.44 nM determined by migration assay with cells expressing recombinant CCR2

Extinction Coefficient

8,730 M-1 cm-1

Endotoxin Level

<0.01 EU per 1mug of the protein by the LAL method

Modification

None

UNSPSC Code

12352202

Product References and Citations for CCL7 active protein

1. "Monocyte chemotactic protein-3" Menten P., Wuyts A., Van Damme J. Eur. Cytokine Netw. 12:554-560 (2002)
2. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Opdenakker G., Froyen G., Fiten P., Proost P., Van Damme J. Biochem. Biophys. Res. Commun. 191: 535-42 (1993)
3. "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist." Blanpain C., Migeotte I., Lee B., Vakili J., Doranz B.J., Govaerts C., Vassart G., Doms R.W., Parmentier M.Blood 94:1899-1905 (1999)

Other Notes

Small volumes of CCL7 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL7 purchase

MBS444006 is an active protein targeting CCL7. Also known as Human CCL7 (MCP-3). Host: E Coli derived.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL7. It may not necessarily be applicable to this product.

NCBI GI #

13435402

NCBI GeneID

6354

NCBI Accession #

NP_006264.2

UniProt Primary Accession #

P80098

UniProt Secondary Accession #

Q569J6

UniProt Related Accession #

P80098

GenBank Nucleotide #

NM_006273.3

NCBI Official Full Name

C-C motif chemokine 7

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 7

NCBI Official Symbol

CCL7

NCBI Official Synonym Symbols

FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7

UniProt Protein Name

C-C motif chemokine 7

UniProt Synonym Protein Names

Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL7

UniProt Synonym Gene Names

MCP3; SCYA6; SCYA7; MCP-3

UniProt Entry Name

CCL7_HUMAN

NCBI Protein Information

C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7

NCBI Summary for CCL7

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

UniProt Comments for CCL7

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; CCR1 chemokine receptor binding; chemokine activity; CCR2 chemokine receptor binding

Biological Process: cellular calcium ion homeostasis; monocyte chemotaxis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; cytoskeleton organization and biogenesis; immune response; inflammatory response; signal transduction; chemotaxis; positive regulation of cell migration

Research Articles on CCL7

1. Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL7 active protein

Reference Product	PubMed Publications
CCL2 active protein	>269 publications with CCL7 and CCL2
CCL5 active protein	>126 publications with CCL7 and CCL5
CCR2 active protein	>93 publications with CCL7 and CCR2
CCL4 active protein	>79 publications with CCL7 and CCL4
CCL3 active protein	>76 publications with CCL7 and CCL3
CCR1 active protein	>45 publications with CCL7 and CCR1
CCR3 active protein	>44 publications with CCL7 and CCR3
CCR5 active protein	>37 publications with CCL7 and CCR5
CXCR3 active protein	>10 publications with CCL7 and CXCR3

Pathways associated with CCL7 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with CCL7 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>200 publications with CCL7 and Inflammation
Lung Diseases Antibodies	>58 publications with CCL7 and Lung Diseases
Necrosis Antibodies	>53 publications with CCL7 and Necrosis
Hypersensitivity Antibodies	>53 publications with CCL7 and Hypersensitivity
Disease Models, Animal Antibodies	>50 publications with CCL7 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>26 publications with CCL7 and Cardiovascular Diseases
Fibrosis Antibodies	>23 publications with CCL7 and Fibrosis
Atherosclerosis Antibodies	>15 publications with CCL7 and Atherosclerosis
Heart Diseases Antibodies	>13 publications with CCL7 and Heart Diseases
Liver Diseases Antibodies	>10 publications with CCL7 and Liver Diseases

Organs/Tissues associated with CCL7 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>283 publications with CCL7 and Blood
Lung Antibodies	>73 publications with CCL7 and Lung
Skin Antibodies	>37 publications with CCL7 and Skin
Intestine Antibodies	>14 publications with CCL7 and Intestine
Uterus Antibodies	>10 publications with CCL7 and Uterus
Placenta Antibodies	>4 publications with CCL7 and Placenta