Human CCL27 Active Protein – Cat# MBS444008

CCL27 Human Active Protein

Name: CCL27 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS444008
Price: 175 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS444008

Cutaneous T-cell-attracting chemokine (CTACK/CCL27) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CTACK, as well… More details

$175 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCL27, Active Protein

Full Product Name

Human CCL27 (CTACK)

Product Gene Name

CCL27 active protein

Product Synonym Names

CCL27 (CTACK)

Sequence

FLLPPSTACC TQLYRKPLSD KLLRKVIQVE LQEADGDCHL QAFVLHLAQR SICIHPQNP SLSQWFEHQE RKLHGTLPKL NFGMLRKMG

Host

E Coli derived

Form/Format

Lyophilized

Purity/Purification

> 97% by SDS PAGE

Preparation and Storage

Avoid repeated freeze-thaw cycles
12 months from date of receipt, -20 to -70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, -20 to -70 degree C under sterile conditions after reconstitution.

Molecular Weight

Actual Molecular Mass: Mass Spec data confirmed expected mass of 10.149kDa
Predicted Molecular Mass: 10.149 kDa

Sequence Positions

25-112

OMIM

604833

3D Structure

ModBase 3D Structure for Q9Y4X3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Reconstitution

Spin sample prior to reconstitution. Recommended at 100mug/mL in sterile water

Carrier Protein

None

Activity

EC50 = 34nM determined by migration assay with cells expressing recombinant CCR10

Extinction Coefficient

7,450 M-1 cm-1

Endotoxin Level

<0.01 EU per 1mug of the protein by the LAL method

Modification

None

UNSPSC Code

12352202

Product References and Citations for CCL27 active protein

1. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey et al. Nature Med. 8: 157-165 (2002)
2. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki et al. FEBS Lett. 460:544-548 (1999)
3. The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function. Gortz A. et al. J Immunol. 169:1387-1394 (2002)

Other Notes

Small volumes of CCL27 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL27 purchase

MBS444008 is an active protein targeting CCL27. Also known as Human CCL27 (CTACK). Host: E Coli derived.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL27. It may not necessarily be applicable to this product.

NCBI GI #

5730035

NCBI GeneID

10850

NCBI Accession #

NP_006655.1

UniProt Primary Accession #

Q9Y4X3

UniProt Related Accession #

Q9Y4X3

GenBank Nucleotide #

NM_006664.3

NCBI Official Full Name

C-C motif chemokine 27

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 27

NCBI Official Symbol

CCL27

NCBI Official Synonym Symbols

ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27

UniProt Synonym Protein Names

CC chemokine ILC; Cutaneous T-cell-attracting chemokine; CTACK; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL27

UniProt Synonym Gene Names

ILC; SCYA27; CTACK

UniProt Entry Name

CCL27_HUMAN

NCBI Protein Information

C-C motif chemokine 27; CC chemokine ILC; IL-11 R-alpha-locus chemokine; IL-11 Ralpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; skinkine; small inducible cytokine subfamily A (Cys-Cys), member 27; small-inducible cytokine A27

NCBI Summary for CCL27

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

UniProt Comments for CCL27

CCL27: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; immune response; chemotaxis

Research Articles on CCL27

1. Findings support the notion that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CCL27 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with CCL27 active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>59 publications with CCL27 and Immune System Diseases
Inflammation Antibodies	>45 publications with CCL27 and Inflammation
Necrosis Antibodies	>33 publications with CCL27 and Necrosis
Drug-Related Side Effects and Adverse Reactions Antibodies	>7 publications with CCL27 and Drug-Related Side Effects and Adverse Reactions
Nervous System Diseases Antibodies	>6 publications with CCL27 and Nervous System Diseases
Liver Diseases Antibodies	>3 publications with CCL27 and Liver Diseases
Lung Diseases Antibodies	>3 publications with CCL27 and Lung Diseases
Liver Neoplasms Antibodies	>2 publications with CCL27 and Liver Neoplasms
Hyperplasia Antibodies	>2 publications with CCL27 and Hyperplasia
Precancerous Conditions Antibodies	>2 publications with CCL27 and Precancerous Conditions

Organs/Tissues associated with CCL27 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>8 publications with CCL27 and Lung
Connective Tissue Antibodies	>5 publications with CCL27 and Connective Tissue
Eye Antibodies	>2 publications with CCL27 and Eye
Testis Antibodies	>2 publications with CCL27 and Testis
Placenta Antibodies	>2 publications with CCL27 and Placenta