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EEA1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS448005
5 units are in stock for immediate shipment. Please contact us for more details.

Early Endosome Antigen 1Goat polyclonal antibody to EEA1 - early endosome marker. EEA1 is Early Endosome Antigen 1 protein that binds phospholipid vesicles containing phosphatidylinositol 3-phosphate, which is necessary for endosomal trafficking. More details

$405 / 0.6 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EEA1, Polyclonal Antibody
Full Product Name
EEA1 Polyclonal Antibody
Product Gene Name
anti-EEA1 antibody
Product Synonym Names
Anti-EEA1; Early endosome antigen 1,162kD; early endosome-associated protein; endosome-associated protein p162; zinc finger FYVE domain-containing protein 2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
human, rat, mouse, canine and monkey proteins.
Form/Format
Polyclonal antibody supplied as (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
Specificity
Detects a band of 180 kDa by Western blot in the following human, mouse and rat whole cell lysates.
Preparation and Storage
For continuous use, store at 2-8 deg;C for one-two days. For extended storage, store in -20 deg;C freezer. Working dilution samples should be discarded if not used within 12 hours.
Molecular Weight
162,466 Da
Chromosome Location
Chromosome: 12; NC_000012.12 (92772245..92929331, complement). Location: 12q22
OMIM
605070
3D Structure
ModBase 3D Structure for Q15075
Gene Identifier
ENSG00000102189
Immunogen
Purified recombinant peptide within residues 1,230 aa to the C-terminus of human EEA1 produced in E. coli.
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-EEA1 antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-EEA1 antibody
Western Blot: 1:250-1:1,000
Immunofluorescence: 1:50-1:250

Reactivity Chart of anti-EEA1 antibody

Goat Anti-EEA1 Polyclonal Antibody – Cat# MBS448005

Testing Data of anti-EEA1 antibody

Goat Anti-EEA1 Polyclonal Antibody, Testing Data – Cat# MBS448005

Other Notes

Small volumes of anti-EEA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EEA1 purchase

MBS448005 is an antibody targeting EEA1. Also known as EEA1 Polyclonal Antibody. Reactive in human, rat, mouse, canine and monkey proteins.. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for EEA1. It may not necessarily be applicable to this product.

NCBI GI #
55770888
NCBI GeneID
8411
NCBI Accession #
NP_003557.2
UniProt Primary Accession #
Q15075
UniProt Secondary Accession #
Q14221
UniProt Related Accession #
Q15075
GenBank Nucleotide #
NM_003566.3
NCBI Official Full Name
early endosome antigen 1
NCBI Official Synonym Full Names
early endosome antigen 1
NCBI Official Symbol
EEA1
NCBI Official Synonym Symbols
MST105; ZFYVE2; MSTP105
UniProt Protein Name
Early endosome antigen 1
UniProt Synonym Protein Names
Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
Protein Family
Early endosome antigen
UniProt Gene Name
EEA1
UniProt Synonym Gene Names
ZFYVE2
UniProt Entry Name
EEA1_HUMAN
NCBI Protein Information
early endosome antigen 1; early endosome antigen 1, 162kD; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2

UniProt Comments for EEA1

Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

Subunit structure: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. May interact with PLEKHF2. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.17 Ref.18

Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein Ref.1 Ref.7 Ref.9 Ref.13 Ref.17.

Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. Ref.14

Miscellaneous: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.

Sequence similarities: Contains 1 C2H2-type zinc finger.Contains 1 FYVE-type zinc finger.
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Research Articles on EEA1

1. We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EEA1 antibody

 Reference Product  PubMed Publications
 RAB5A antibody  >12 publications with EEA1 and RAB5A
 ZFYVE20 antibody  >3 publications with EEA1 and ZFYVE20
 RABGEF1 antibody  >2 publications with EEA1 and RABGEF1
 RAB5C antibody  >2 publications with EEA1 and RAB5C
 RAB5B antibody  >2 publications with EEA1 and RAB5B
 TLR9 antibody  >1 publications with EEA1 and TLR9

Pathways associated with anti-EEA1 antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Toll Like Receptor 9 (TLR9) Cascade Pathway antibodies  Toll Like Receptor 9 (TLR9) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-EEA1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >6 publications with EEA1 and Kidney Diseases
 Central Nervous System Diseases Antibodies  >6 publications with EEA1 and Central Nervous System Diseases
 Carcinoma Antibodies  >6 publications with EEA1 and Carcinoma
 Inflammation Antibodies  >6 publications with EEA1 and Inflammation
 Necrosis Antibodies  >6 publications with EEA1 and Necrosis
 Disease Models, Animal Antibodies  >5 publications with EEA1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >4 publications with EEA1 and Lung Neoplasms
 Edema Antibodies  >3 publications with EEA1 and Edema
 Carcinoma, Hepatocellular Antibodies  >3 publications with EEA1 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >3 publications with EEA1 and Atherosclerosis

Organs/Tissues associated with anti-EEA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with EEA1 and Brain
 Blood Antibodies  >33 publications with EEA1 and Blood
 Nerve Antibodies  >27 publications with EEA1 and Nerve
 Kidney Antibodies  >25 publications with EEA1 and Kidney
 Liver Antibodies  >16 publications with EEA1 and Liver
 Lung Antibodies  >16 publications with EEA1 and Lung
 Muscle Antibodies  >13 publications with EEA1 and Muscle
 Vascular Antibodies  >11 publications with EEA1 and Vascular
 Bone Antibodies  >7 publications with EEA1 and Bone
 Intestine Antibodies  >6 publications with EEA1 and Intestine
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