CAV2 Antibody – Goat Polyclonal

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: Golgi apparatus; protein complex; focal adhesion; integral to plasma membrane; caveola; acrosomal membrane; lipid raft; Golgi membrane; extrinsic to internal side of plasma membrane; transport vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; intracellular; cytoplasmic vesicle; nucleus

Molecular Function: protein binding; protein homodimerization activity; D1 dopamine receptor binding

Biological Process: endoplasmic reticulum organization and biogenesis; mitochondrion organization and biogenesis; positive regulation of dopamine receptor signaling pathway; vesicle organization and biogenesis; skeletal muscle fiber development; protein oligomerization; vesicle fusion; vesicle docking; positive regulation of MAPKKK cascade; negative regulation of endothelial cell proliferation; insulin receptor signaling pathway; regulation of mitosis; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of GTPase activity