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CYSLTR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4508968

MBS4508968 is an antibody targeting CYSLTR1. Also known as Rabbit anti-CYSLTR1 Antibody. Reactive in Human, Monkey. Host: Rabbit. More details

$265 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYSLTR1, Polyclonal Antibody
Full Product Name
Rabbit anti-CYSLTR1 Antibody
Product Gene Name
anti-CYSLTR1 antibody
Product Synonym Names
CYSLT1; Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
38,541 Da
Chromosome Location
Chromosome: X; NC_000023.10 (77528130..77583087, complement). Location: Xq13.2-q21.1
OMIM
300201
3D Structure
ModBase 3D Structure for Q9Y271
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CYSLTR1. The exact sequence is proprietary.

Product Categories/Family for anti-CYSLTR1 antibody

Primary antibodies
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CYSLTR1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochemistry (IC)
Application Notes for anti-CYSLTR1 antibody
WB: 1:500-1:1000
IHC: 1:100-1:200
IF:IC: 1:100-1:500

Western Blot (WB) of anti-CYSLTR1 antibody

Western blot analysis of CYSLTR1 expression in Jurkat (A), HUVEC (B), COS7 (C) whole cell lysates.
Rabbit Anti-CYSLTR1 Polyclonal Antibody – Cat# MBS4508968

Immunohistochemistry (IHC) of anti-CYSLTR1 antibody

Immunohistochemical analysis of CYSLTR1 staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-CYSLTR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4508968

Immunofluorescence (IF) of anti-CYSLTR1 antibody

Immunofluorescent analysis of CYSLTR1 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-CYSLTR1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS4508968

Other Notes

Small volumes of anti-CYSLTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYSLTR1. It may not necessarily be applicable to this product.

NCBI GI #
5729798
NCBI GeneID
10800
NCBI Accession #
NP_006630.1
UniProt Primary Accession #
Q9Y271
UniProt Secondary Accession #
Q5JS94; Q8IV19; B2R954; D3DTE4
UniProt Related Accession #
Q9Y271
GenBank Nucleotide #
NM_006639.2
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Symbol
CYSLTR1
NCBI Official Synonym Symbols
HG55; CYSLT1; CYSLTR; CYSLT1R; HMTMF81
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
Protein Family
Cysteinyl leukotriene receptor
UniProt Gene Name
CYSLTR1
UniProt Synonym Gene Names
CYSLT1; CysLTR1
UniProt Entry Name
CLTR1_HUMAN
NCBI Protein Information
cysteinyl leukotriene receptor 1; LTD4 receptor; G-protein coupled receptor HG55; cysteinyl leukotriene D4 receptor

NCBI Summary for CYSLTR1

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYSLTR1

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq13.2-q21.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; inflammatory response; chemotaxis
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Research Articles on CYSLTR1

1. Genetic variant may play a role in NSAID induced acute urticaria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CYSLTR1 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with anti-CYSLTR1 antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >39 publications with CYSLTR1 and Asthma
 Inflammation Antibodies  >12 publications with CYSLTR1 and Inflammation
 Drug Hypersensitivity Antibodies  >10 publications with CYSLTR1 and Drug Hypersensitivity
 Asthma, Aspirin-Induced Antibodies  >8 publications with CYSLTR1 and Asthma, Aspirin-Induced
 Rhinitis Antibodies  >6 publications with CYSLTR1 and Rhinitis
 Urticaria Antibodies  >5 publications with CYSLTR1 and Urticaria
 Necrosis Antibodies  >3 publications with CYSLTR1 and Necrosis
 Fibrosis Antibodies  >2 publications with CYSLTR1 and Fibrosis
 Asthma, Exercise-Induced Antibodies  >2 publications with CYSLTR1 and Asthma, Exercise-Induced
 Musculoskeletal Diseases Antibodies  >2 publications with CYSLTR1 and Musculoskeletal Diseases

Organs/Tissues associated with anti-CYSLTR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with CYSLTR1 and Blood
 Connective Tissue Antibodies  >1 publications with CYSLTR1 and Connective Tissue
 Lymph Node Antibodies  >1 publications with CYSLTR1 and Lymph Node
 Trachea Antibodies  >1 publications with CYSLTR1 and Trachea
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