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ACAS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4510322

MBS4510322 is an antibody targeting ACAS2. Also known as Rabbit anti-ACAS2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$265 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACAS2, Polyclonal Antibody
Full Product Name
Rabbit anti-ACAS2 Antibody
Product Gene Name
anti-ACAS2 antibody
Product Synonym Names
ACAS2; Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
78,580 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (33462766..33515769). Location: 20q11.22
OMIM
605832
3D Structure
ModBase 3D Structure for Q9NR19
Immunogen
Recombinant full length protein of human ACAS2

Product Categories/Family for anti-ACAS2 antibody

Primary antibodies
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ACAS2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunochemistry (IC)
Application Notes for anti-ACAS2 antibody
WB: 1:500-1:2000
IF:IC: 1:10-1:100

Western Blot (WB) of anti-ACAS2 antibody

Western blot analysis of ACAS2 expression in HepG2 (A), SW620 (B), mouse liver (C), mouse kidney (D), rat brain (E) whole cell lysates.
Rabbit Anti-ACAS2 Polyclonal Antibody – Cat# MBS4510322

Immunofluorescence (IF) of anti-ACAS2 antibody

Immunofluorescent analysis of ACAS2 staining in SW620 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Rabbit Anti-ACAS2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS4510322

Other Notes

Small volumes of anti-ACAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACAS2. It may not necessarily be applicable to this product.

NCBI GI #
253970489
NCBI GeneID
55902
NCBI Accession #
NP_001070020.2
UniProt Primary Accession #
Q9NR19
UniProt Secondary Accession #
Q9QXG4
UniProt Related Accession #
Q9NR19
GenBank Nucleotide #
NM_001076552.2
NCBI Official Full Name
acetyl-coenzyme A synthetase, cytoplasmic isoform 2
NCBI Official Synonym Full Names
acyl-CoA synthetase short-chain family member 2
NCBI Official Symbol
ACSS2
NCBI Official Synonym Symbols
ACS; ACSA; ACAS2; ACECS; dJ1161H23.1
UniProt Protein Name
Acetyl-coenzyme A synthetase, cytoplasmic
UniProt Synonym Protein Names
Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme
UniProt Gene Name
ACSS2
UniProt Synonym Gene Names
ACAS2; ACS; AceCS
UniProt Entry Name
ACSA_HUMAN
NCBI Protein Information
acetyl-coenzyme A synthetase, cytoplasmic; acetate thiokinase; acetate-CoA ligase; acyl-activating enzyme; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming)

NCBI Summary for ACAS2

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
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UniProt Comments for ACAS2

ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Ligase; EC 6.2.1.1; Carbohydrate Metabolism - pyruvate

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; cytosol

Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding

Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; ethanol oxidation; propionate biosynthetic process; acetate biosynthetic process
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Research Articles on ACAS2

1. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACAS2 antibody

 Products by Pathway  Pathway Diagram
 Amino Acid Conjugation Of Benzoic Acid Pathway antibodies  Amino Acid Conjugation Of Benzoic Acid Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Propanoate Metabolism Pathway antibodies  Propanoate Metabolism Pathway Diagram

Diseases associated with anti-ACAS2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with ACAS2 and Neoplasms
 Insulin Resistance Antibodies  >3 publications with ACAS2 and Insulin Resistance
 Hyperglycemia Antibodies  >2 publications with ACAS2 and Hyperglycemia
 Weight Gain Antibodies  >2 publications with ACAS2 and Weight Gain
 Atherosclerosis Antibodies  >2 publications with ACAS2 and Atherosclerosis
 Fatty Liver Antibodies  >2 publications with ACAS2 and Fatty Liver
 Breast Neoplasms Antibodies  >1 publications with ACAS2 and Breast Neoplasms
 Drug Toxicity Antibodies  >1 publications with ACAS2 and Drug Toxicity
 Carcinoma, Hepatocellular Antibodies  >1 publications with ACAS2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with ACAS2 and Inflammation

Organs/Tissues associated with anti-ACAS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with ACAS2 and Blood
 Liver Antibodies  >4 publications with ACAS2 and Liver
 Connective Tissue Antibodies  >3 publications with ACAS2 and Connective Tissue
 Heart Antibodies  >2 publications with ACAS2 and Heart
 Mammary Gland Antibodies  >1 publications with ACAS2 and Mammary Gland
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