Mothers Against Decapentaplegic Homolog 7 (SMAD7) ELISA Kit for Human

Name: Human SMAD7 ELISA Kit; Mothers Against Decapentaplegic Homolog 7; MyBioSource
Brand: MyBioSource
SKU: MBS451223
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS451223

MBS451223 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mothers Against Decapentaplegic Homolog 7 (Smad7) ELISA Kit target analytes in biological samples. The concentration… More details

$480 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit

Full Product Name

Human Mothers Against Decapentaplegic Homolog 7 (Smad7) ELISA Kit

Product Gene Name

Smad7 elisa kit

Product Synonym Names

MADH7; MADH8; Mothers against DPP homolog 8

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.156-10ng/mL

Sensitivity

0.056ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

46,355 Da

OMIM

AF010193 mRNA

3D Structure

ModBase 3D Structure for O15105

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of Smad7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Smad7. It may not necessarily be applicable to this product.

NCBI GI #

299890805

NCBI GeneID

4092

NCBI Accession #

NP_001177750.1

UniProt Primary Accession #

O15105

UniProt Secondary Accession #

O14740; Q6DK23; B7Z773; K7EQ10

UniProt Related Accession #

O15105

GenBank Nucleotide #

NM_001190821.1

NCBI Official Full Name

mothers against decapentaplegic homolog 7 isoform 2

NCBI Official Synonym Full Names

SMAD family member 7

NCBI Official Symbol

SMAD7

NCBI Official Synonym Symbols

CRCS3; MADH7; MADH8

UniProt Protein Name

Mothers against decapentaplegic homolog 7

UniProt Synonym Protein Names

Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7

Protein Family

Mothers against decapentaplegic

UniProt Gene Name

SMAD7

UniProt Synonym Gene Names

MADH7; MADH8; MAD homolog 7; Mothers against DPP homolog 7; MAD homolog 8; Mothers against DPP homolog 8; SMAD 7; Smad7; hSMAD7

NCBI Protein Information

mothers against decapentaplegic homolog 7

NCBI Summary for Smad7

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

UniProt Comments for Smad7

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Research Articles on Smad7

1. SMAD7 overexpression might represent a mechanism limiting TGF-beta-mediated fibrogenesis in human hepatic diseases; therefore, SMAD7 induction likely represents a candidate for novel therapeutic approaches.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Smad7 elisa kit

Reference Product	PubMed Publications
TGFB1 elisa kit	>650 publications with Smad7 and TGFB1
SMURF1 elisa kit	>34 publications with Smad7 and SMURF1
CTNNB1 elisa kit	>33 publications with Smad7 and CTNNB1
TGFBR1 elisa kit	>17 publications with Smad7 and TGFBR1
BMPR1A elisa kit	>12 publications with Smad7 and BMPR1A
HDAC1 elisa kit	>5 publications with Smad7 and HDAC1
WWP1 elisa kit	>4 publications with Smad7 and WWP1
YAP1 elisa kit	>2 publications with Smad7 and YAP1
UBC elisa kit	>2 publications with Smad7 and UBC

Pathways associated with Smad7 elisa kit

Products by Pathway	Pathway Diagram
ALK1 Signaling Events Pathway antibodies	ALK1 Signaling Events Pathway Diagram
Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway antibodies	Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Deubiquitination Pathway antibodies	Deubiquitination Pathway Diagram
Downregulation Of TGF-beta Receptor Signaling Pathway antibodies	Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Hfe Effect On Hepcidin Production Pathway antibodies	Hfe Effect On Hepcidin Production Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram

Diseases associated with Smad7 elisa kit

Disease Name	Pubmed Publications
Fibrosis Antibodies	>444 publications with Smad7 and Fibrosis
Inflammation Antibodies	>180 publications with Smad7 and Inflammation
Disease Models, Animal Antibodies	>155 publications with Smad7 and Disease Models, Animal
Liver Diseases Antibodies	>139 publications with Smad7 and Liver Diseases
Kidney Diseases Antibodies	>125 publications with Smad7 and Kidney Diseases
Lung Diseases Antibodies	>90 publications with Smad7 and Lung Diseases
Necrosis Antibodies	>84 publications with Smad7 and Necrosis
Liver Cirrhosis Antibodies	>77 publications with Smad7 and Liver Cirrhosis
Cardiovascular Diseases Antibodies	>73 publications with Smad7 and Cardiovascular Diseases
Adenocarcinoma Antibodies	>70 publications with Smad7 and Adenocarcinoma

Organs/Tissues associated with Smad7 elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>247 publications with Smad7 and Muscle
Bone Antibodies	>245 publications with Smad7 and Bone
Blood Antibodies	>227 publications with Smad7 and Blood
Kidney Antibodies	>206 publications with Smad7 and Kidney
Lung Antibodies	>131 publications with Smad7 and Lung
Connective Tissue Antibodies	>118 publications with Smad7 and Connective Tissue
Vascular Antibodies	>113 publications with Smad7 and Vascular
Heart Antibodies	>84 publications with Smad7 and Heart
Embryonic Tissue Antibodies	>64 publications with Smad7 and Embryonic Tissue
Eye Antibodies	>45 publications with Smad7 and Eye