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Low Density Lipoprotein Receptor Related Protein 6 (LRP6) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS451681

MBS451681 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Low Density Lipoprotein Receptor Related Protein 6 (LRP6) ELISA Kit target analytes in biological samples. The… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Low Density Lipoprotein Receptor Related Protein 6 (LRP6), ELISA Kit
Full Product Name
Human Low Density Lipoprotein Receptor Related Protein 6 (LRP6) ELISA Kit
Product Gene Name
LRP6 elisa kit
Product Synonym Names
LRP6
Species Reactivity
Human
Assay Type
Sandwich
Samples
Tissue homogenates and other biological fluids.
Detection Range
0.156-10ng/mL
Sensitivity
0.059ng/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
180,429 Da
OMIM
AF074264 mRNA
3D Structure
ModBase 3D Structure for O75581
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of LRP6 elisa kit

Human LRP6 ELISA Kit – Cat# MBS451681

Other Notes

Small volumes of LRP6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LRP6. It may not necessarily be applicable to this product.

NCBI GI #
148727288
NCBI GeneID
4040
NCBI Accession #
NP_002327.2
UniProt Primary Accession #
O75581
UniProt Secondary Accession #
Q17RZ2
UniProt Related Accession #
O75581
GenBank Nucleotide #
NM_002336.2
NCBI Official Full Name
low-density lipoprotein receptor-related protein 6
NCBI Official Synonym Full Names
LDL receptor related protein 6
NCBI Official Symbol
LRP6
NCBI Official Synonym Symbols
ADCAD2; STHAG7
UniProt Protein Name
Low-density lipoprotein receptor-related protein 6
Protein Family
Low-density lipoprotein receptor-related protein
UniProt Gene Name
LRP6
UniProt Synonym Gene Names
LRP-6
NCBI Protein Information
low-density lipoprotein receptor-related protein 6

NCBI Summary for LRP6

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
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UniProt Comments for LRP6

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation ().
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Research Articles on LRP6

1. Accordingly, we propose that the anti-fibrotic activity of adiponectin may be mediated through AdipoR1/R2 receptors

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LRP6 elisa kit

 Reference Product  PubMed Publications
 WNT3A elisa kit  >122 publications with LRP6 and WNT3A
 DKK1 elisa kit  >120 publications with LRP6 and DKK1
 WNT1 elisa kit  >50 publications with LRP6 and WNT1
 WNT5A elisa kit  >39 publications with LRP6 and WNT5A
 GSK3B elisa kit  >26 publications with LRP6 and GSK3B
 AXIN1 elisa kit  >22 publications with LRP6 and AXIN1
 DKK2 elisa kit  >21 publications with LRP6 and DKK2
 FZD5 elisa kit  >14 publications with LRP6 and FZD5
 FZD8 elisa kit  >7 publications with LRP6 and FZD8
 DVL1 elisa kit  >5 publications with LRP6 and DVL1

Pathways associated with LRP6 elisa kit

 Products by Pathway  Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Primary Focal Segmental Glomerulosclerosis FSGS Pathway antibodies  Primary Focal Segmental Glomerulosclerosis FSGS Pathway Diagram

Diseases associated with LRP6 elisa kit

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >35 publications with LRP6 and Carcinoma
 Inflammation Antibodies  >31 publications with LRP6 and Inflammation
 Breast Neoplasms Antibodies  >25 publications with LRP6 and Breast Neoplasms
 Liver Diseases Antibodies  >16 publications with LRP6 and Liver Diseases
 Fibrosis Antibodies  >13 publications with LRP6 and Fibrosis
 Neoplasm Metastasis Antibodies  >13 publications with LRP6 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >12 publications with LRP6 and Kidney Diseases
 Neoplasm Invasiveness Antibodies  >10 publications with LRP6 and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >10 publications with LRP6 and Liver Neoplasms
 Embryo Loss Antibodies  >9 publications with LRP6 and Embryo Loss

Organs/Tissues associated with LRP6 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >157 publications with LRP6 and Bone
 Blood Antibodies  >50 publications with LRP6 and Blood
 Embryonic Tissue Antibodies  >46 publications with LRP6 and Embryonic Tissue
 Brain Antibodies  >46 publications with LRP6 and Brain
 Liver Antibodies  >34 publications with LRP6 and Liver
 Eye Antibodies  >32 publications with LRP6 and Eye
 Muscle Antibodies  >25 publications with LRP6 and Muscle
 Lung Antibodies  >22 publications with LRP6 and Lung
 Heart Antibodies  >21 publications with LRP6 and Heart
 Kidney Antibodies  >19 publications with LRP6 and Kidney
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