Mineralocorticoid Receptor (MR) ELISA Kit for Human

Name: Human MR ELISA Kit; Mineralocorticoid Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS453255
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS453255

MBS453255 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mineralocorticoid Receptor (MR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$480 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Mineralocorticoid Receptor (MR), ELISA Kit

Full Product Name

Human Mineralocorticoid Receptor (MR) ELISA Kit

Product Gene Name

MR elisa kit

Product Synonym Names

ITG-B4; CD104

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.112ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

94,359 Da

OMIM

M16801 mRNA

3D Structure

ModBase 3D Structure for P08235

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of MR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MR. It may not necessarily be applicable to this product.

NCBI GI #

158508572

NCBI GeneID

4306

NCBI Accession #

NP_000892.2

UniProt Primary Accession #

P08235

UniProt Secondary Accession #

Q2NKL1; Q96KQ8; Q96KQ9; B0ZBF5; B0ZBF7

UniProt Related Accession #

P08235

GenBank Nucleotide #

NM_000901.4

NCBI Official Full Name

mineralocorticoid receptor isoform 1

NCBI Official Synonym Full Names

nuclear receptor subfamily 3 group C member 2

NCBI Official Symbol

NR3C2

NCBI Official Synonym Symbols

MR; MCR; MLR; NR3C2VIT

UniProt Protein Name

Mineralocorticoid receptor

UniProt Synonym Protein Names

Nuclear receptor subfamily 3 group C member 2

Protein Family

Mineralocorticoid receptor

UniProt Gene Name

NR3C2

UniProt Synonym Gene Names

MCR; MLR; MR

NCBI Protein Information

mineralocorticoid receptor

NCBI Summary for MR

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

UniProt Comments for MR

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Research Articles on MR

1. dysregulation of GR, MR, FKBP5, and PTGES3 in autistic spectrum disorder (ASD) and suggest a possible role of inflammation in altered GR function in ASD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MR elisa kit

Reference Product	PubMed Publications
SCNN1A elisa kit	>9 publications with MR and SCNN1A
SGK1 elisa kit	>3 publications with MR and SGK1
FKBP4 elisa kit	>2 publications with MR and FKBP4
SRC elisa kit	>1 publications with MR and SRC
UBC elisa kit	>1 publications with MR and UBC

Pathways associated with MR elisa kit

Products by Pathway	Pathway Diagram
ACE Inhibitor Pathway antibodies	ACE Inhibitor Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Preimplantation Embryo Pathway antibodies	Preimplantation Embryo Pathway Diagram

Diseases associated with MR elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>24 publications with MR and Cardiovascular Diseases
Hypertension Antibodies	>23 publications with MR and Hypertension
Pseudohypoaldosteronism Antibodies	>23 publications with MR and Pseudohypoaldosteronism
Kidney Diseases Antibodies	>20 publications with MR and Kidney Diseases
Vascular Diseases Antibodies	>16 publications with MR and Vascular Diseases
Heart Diseases Antibodies	>8 publications with MR and Heart Diseases
Weight Loss Antibodies	>6 publications with MR and Weight Loss
Prenatal Exposure Delayed Effects Antibodies	>6 publications with MR and Prenatal Exposure Delayed Effects
Heart Failure Antibodies	>6 publications with MR and Heart Failure
Depressive Disorder Antibodies	>6 publications with MR and Depressive Disorder

Organs/Tissues associated with MR elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>38 publications with MR and Brain
Kidney Antibodies	>13 publications with MR and Kidney
Vascular Antibodies	>10 publications with MR and Vascular
Liver Antibodies	>6 publications with MR and Liver
Lung Antibodies	>5 publications with MR and Lung
Muscle Antibodies	>4 publications with MR and Muscle
Embryonic Tissue Antibodies	>3 publications with MR and Embryonic Tissue
Placenta Antibodies	>3 publications with MR and Placenta
Testis Antibodies	>2 publications with MR and Testis
Intestine Antibodies	>1 publications with MR and Intestine