Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) ELISA Kit for Human

Name: Human MANF ELISA Kit; Mesencephalic Astrocyte Derived Neurotrophic Factor; MyBioSource
Brand: MyBioSource
SKU: MBS453749
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS453749

MBS453749 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) ELISA Kit target analytes in biological samples. The… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF), ELISA Kit

Full Product Name

Human Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) ELISA Kit

Product Gene Name

MANF elisa kit

Product Synonym Names

ARMET; ARP; Arginine Rich Mutated In Early Stage Tumors; Arginine-rich protein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Detection Range

15.625-1000pg/mL

Sensitivity

6.7pg/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

20,700 Da

OMIM

M83751 mRNA

3D Structure

ModBase 3D Structure for P55145

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of MANF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MANF. It may not necessarily be applicable to this product.

NCBI GI #

618857509

NCBI GeneID

7873

NCBI Accession #

NP_006001.4

UniProt Primary Accession #

P55145

UniProt Secondary Accession #

Q14CX4; Q86U67; Q96IS4

UniProt Related Accession #

P55145

GenBank Nucleotide #

NM_006010.5

NCBI Official Full Name

mesencephalic astrocyte-derived neurotrophic factor

NCBI Official Synonym Full Names

mesencephalic astrocyte derived neurotrophic factor

NCBI Official Symbol

MANF

NCBI Official Synonym Symbols

ARP; ARMET

UniProt Protein Name

Mesencephalic astrocyte-derived neurotrophic factor

UniProt Synonym Protein Names

Arginine-rich protein; Protein ARMET

Protein Family

Alpha-mannosidase

UniProt Gene Name

MANF

UniProt Synonym Gene Names

ARMET; ARP

NCBI Protein Information

mesencephalic astrocyte-derived neurotrophic factor

NCBI Summary for MANF

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

UniProt Comments for MANF

Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Research Articles on MANF

1. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MANF elisa kit

Reference Product	PubMed Publications
HSPA5 elisa kit	>2 publications with MANF and HSPA5
HYOU1 elisa kit	>1 publications with MANF and HYOU1
MATN3 elisa kit	>1 publications with MANF and MATN3
HSP90B1 elisa kit	>1 publications with MANF and HSP90B1

Pathways associated with MANF elisa kit

Products by Pathway	Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with MANF elisa kit

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>19 publications with MANF and Disease Models, Animal
Cardiovascular Diseases Antibodies	>11 publications with MANF and Cardiovascular Diseases
Nerve Degeneration Antibodies	>11 publications with MANF and Nerve Degeneration
Kidney Diseases Antibodies	>3 publications with MANF and Kidney Diseases
Inflammation Antibodies	>3 publications with MANF and Inflammation
Heart Diseases Antibodies	>3 publications with MANF and Heart Diseases
Necrosis Antibodies	>3 publications with MANF and Necrosis
Adenocarcinoma Antibodies	>2 publications with MANF and Adenocarcinoma
Hypertrophy Antibodies	>2 publications with MANF and Hypertrophy
Lung Neoplasms Antibodies	>2 publications with MANF and Lung Neoplasms

Organs/Tissues associated with MANF elisa kit

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>78 publications with MANF and Nerve
Brain Antibodies	>36 publications with MANF and Brain
Blood Antibodies	>8 publications with MANF and Blood
Embryonic Tissue Antibodies	>7 publications with MANF and Embryonic Tissue
Heart Antibodies	>4 publications with MANF and Heart
Vascular Antibodies	>3 publications with MANF and Vascular
Bone Antibodies	>3 publications with MANF and Bone
Kidney Antibodies	>3 publications with MANF and Kidney
Lung Antibodies	>2 publications with MANF and Lung
Connective Tissue Antibodies	>1 publications with MANF and Connective Tissue