Human PPARgC1a ELISA Kit – Cat# MBS453938

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit for Human

Name: Human PPARgC1a ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS453938
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS453938

MBS453938 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit target analytes in biological… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), ELISA Kit

Full Product Name

Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit

Product Gene Name

PPARgC1a elisa kit

Product Synonym Names

LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1; Ligand effect modulator 6

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.156-10ng/mL

Sensitivity

0.061ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

77,139 Da

3D Structure

ModBase 3D Structure for Q9UBK2

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of PPARgC1a elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPARgC1a. It may not necessarily be applicable to this product.

NCBI GI #

7019499

NCBI GeneID

10891

NCBI Accession #

NP_037393.1

UniProt Primary Accession #

Q9UBK2

UniProt Secondary Accession #

Q3LIG1; Q4W5M7; Q9UN32; B7Z406; G8DM16; I3RTT5; I3RTT6; I3RTT7; I3RTT8; I3RTT9

UniProt Related Accession #

Q9UBK2

GenBank Nucleotide #

NM_013261.4

NCBI Official Full Name

peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 2

NCBI Official Synonym Full Names

PPARG coactivator 1 alpha

NCBI Official Symbol

PPARGC1A

NCBI Official Synonym Symbols

LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha)

UniProt Protein Name

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

UniProt Synonym Protein Names

Ligand effect modulator 6

Protein Family

Peroxisome proliferator-activated receptor gamma coactivator

UniProt Gene Name

PPARGC1A

UniProt Synonym Gene Names

LEM6; PGC1; PGC1A; PPARGC1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha

NCBI Protein Information

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

NCBI Summary for PPARgC1a

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

UniProt Comments for PPARgC1a

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Research Articles on PPARgC1a

1. Recent findings on the PGC1alpha/FNDC5/BDNF pathway and its role in neuroprotection, and the controversial promise of the FNDC5 peptide irisin as a mediator of the positive benefits of exercise are discussed. Review.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPARgC1a elisa kit

Reference Product	PubMed Publications
SIRT1 elisa kit	>254 publications with PPARgC1a and SIRT1
NRF1 elisa kit	>92 publications with PPARgC1a and NRF1
SLC2A4 elisa kit	>59 publications with PPARgC1a and SLC2A4
PPARG elisa kit	>51 publications with PPARgC1a and PPARG
SIRT3 elisa kit	>37 publications with PPARgC1a and SIRT3
HNF4A elisa kit	>32 publications with PPARgC1a and HNF4A
CREB1 elisa kit	>27 publications with PPARgC1a and CREB1
PPARA elisa kit	>27 publications with PPARgC1a and PPARA
ESRRA elisa kit	>7 publications with PPARgC1a and ESRRA
MAPK14 elisa kit	>2 publications with PPARgC1a and MAPK14

Pathways associated with PPARgC1a elisa kit

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway antibodies	Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies	BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
Circadian Clock Pathway antibodies	Circadian Clock Pathway Diagram
Circadian Rythm Related Genes Pathway antibodies	Circadian Rythm Related Genes Pathway Diagram

Diseases associated with PPARgC1a elisa kit

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>318 publications with PPARgC1a and Insulin Resistance
Cardiovascular Diseases Antibodies	>246 publications with PPARgC1a and Cardiovascular Diseases
Disease Models, Animal Antibodies	>228 publications with PPARgC1a and Disease Models, Animal
Fatty Liver Antibodies	>190 publications with PPARgC1a and Fatty Liver
Inflammation Antibodies	>182 publications with PPARgC1a and Inflammation
Liver Diseases Antibodies	>159 publications with PPARgC1a and Liver Diseases
Heart Diseases Antibodies	>152 publications with PPARgC1a and Heart Diseases
Diabetes Mellitus, Type 2 Antibodies	>151 publications with PPARgC1a and Diabetes Mellitus, Type 2
Hyperglycemia Antibodies	>100 publications with PPARgC1a and Hyperglycemia
Hypertrophy Antibodies	>88 publications with PPARgC1a and Hypertrophy

Organs/Tissues associated with PPARgC1a elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>1117 publications with PPARgC1a and Muscle
Liver Antibodies	>534 publications with PPARgC1a and Liver
Heart Antibodies	>306 publications with PPARgC1a and Heart
Connective Tissue Antibodies	>266 publications with PPARgC1a and Connective Tissue
Brain Antibodies	>251 publications with PPARgC1a and Brain
Kidney Antibodies	>93 publications with PPARgC1a and Kidney
Thyroid Antibodies	>44 publications with PPARgC1a and Thyroid
Embryonic Tissue Antibodies	>39 publications with PPARgC1a and Embryonic Tissue
Pancreas Antibodies	>37 publications with PPARgC1a and Pancreas
Lung Antibodies	>37 publications with PPARgC1a and Lung