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Pregnancy Zone (PZP) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454011

MBS454011 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pregnancy Zone Protein (PZP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pregnancy Zone Protein (PZP), ELISA Kit
Full Product Name
Human Pregnancy Zone Protein (PZP) ELISA Kit
Product Gene Name
PZP elisa kit
Product Synonym Names
CPAMD6; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Species Reactivity
Human
Assay Type
Sandwich
Samples
Serum, plasma, tissue homogenates and other biological fluids.
Detection Range
62.5-4000pg/mL
Sensitivity
32.7pg/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
140,368 Da
OMIM
X54380 mRNA
3D Structure
ModBase 3D Structure for P20742
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of PZP elisa kit

Human PZP ELISA Kit – Cat# MBS454011

Other Notes

Small volumes of PZP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PZP. It may not necessarily be applicable to this product.

NCBI GI #
281185515
NCBI GeneID
5858
UniProt Primary Accession #
P20742
UniProt Secondary Accession #
Q15273; Q2NKL2; Q7M4N7; A6ND27
UniProt Related Accession #
P20742
NCBI Official Full Name
Pregnancy zone protein
NCBI Official Synonym Full Names
PZP, alpha-2-macroglobulin like
NCBI Official Symbol
PZP
NCBI Official Synonym Symbols
CPAMD6
UniProt Protein Name
Pregnancy zone protein
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Protein Family
Pregnancy zone protein
UniProt Gene Name
PZP
UniProt Synonym Gene Names
CPAMD6
NCBI Protein Information
pregnancy zone protein

NCBI Summary for PZP

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
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UniProt Comments for PZP

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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Research Articles on PZP

1. The data of this study link the finding of elevated serum PZP levels with the characteristic Alzheimer's Disease pathology and identify PZP as a novel component in Alzheimer's Disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with PZP elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with PZP and Brain
 Liver Antibodies  >14 publications with PZP and Liver
 Uterus Antibodies  >5 publications with PZP and Uterus
 Lung Antibodies  >2 publications with PZP and Lung
 Trachea Antibodies  >1 publications with PZP and Trachea
 Testis Antibodies  >1 publications with PZP and Testis
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