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Glucoprotein 130 (gp130) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454045

MBS454045 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glucoprotein 130 (gp130) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$485 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glucoprotein 130 (gp130), ELISA Kit
Full Product Name
Mouse Glucoprotein 130 (gp130) ELISA Kit
Product Gene Name
gp130 elisa kit
Product Synonym Names
CDw130; CD130; IL6ST; GP130-RAPS; IR6RB; IL6R-Beta; IR6RB; IR6-RB; Interleukin 6 Signal Transducer; Oncostatin M Receptor; Interleukin-6 Receptor Subunit Beta
Species Reactivity
Mouse
Assay Type
Sandwich
Samples
Serum, plasma and other biological fluids.
Detection Range
125-8000pg/mL
Sensitivity
48pg/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
102,451 Da
3D Structure
ModBase 3D Structure for Q00560
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of gp130 elisa kit

Mouse gp130 ELISA Kit – Cat# MBS454045

Other Notes

Small volumes of gp130 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for gp130. It may not necessarily be applicable to this product.

NCBI GI #
225007625
NCBI GeneID
16195
NCBI Accession #
NP_034690.3
UniProt Primary Accession #
Q00560
UniProt Secondary Accession #
G5E8D2
UniProt Related Accession #
Q00560
GenBank Nucleotide #
NM_010560.3
NCBI Official Full Name
interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
NCBI Protein Information
interleukin-6 receptor subunit beta

UniProt Comments for gp130

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).
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Research Articles on gp130

1. Results suggest that the protective role of gp130-dependent STAT3 activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with gp130 elisa kit

 Reference Product  PubMed Publications
 Lif elisa kit  >242 publications with gp130 and Lif
 Cntf elisa kit  >117 publications with gp130 and Cntf
 Il6 elisa kit  >64 publications with gp130 and Il6
 Jak1 elisa kit  >58 publications with gp130 and Jak1
 Jak2 elisa kit  >50 publications with gp130 and Jak2
 Socs3 elisa kit  >38 publications with gp130 and Socs3
 Ptpn11 elisa kit  >32 publications with gp130 and Ptpn11
 Tyk2 elisa kit  >21 publications with gp130 and Tyk2
 Jak3 elisa kit  >6 publications with gp130 and Jak3
 Il6ra elisa kit  >1 publications with gp130 and Il6ra

Pathways associated with gp130 elisa kit

 Products by Pathway  Pathway Diagram
 Adipogenesis Genes Pathway antibodies  Adipogenesis Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram

Diseases associated with gp130 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >131 publications with gp130 and Inflammation
 Cardiovascular Diseases Antibodies  >107 publications with gp130 and Cardiovascular Diseases
 Carcinoma Antibodies  >64 publications with gp130 and Carcinoma
 Disease Models, Animal Antibodies  >62 publications with gp130 and Disease Models, Animal
 Nervous System Diseases Antibodies  >56 publications with gp130 and Nervous System Diseases
 Heart Diseases Antibodies  >50 publications with gp130 and Heart Diseases
 Necrosis Antibodies  >47 publications with gp130 and Necrosis
 Liver Diseases Antibodies  >44 publications with gp130 and Liver Diseases
 Hypertrophy Antibodies  >31 publications with gp130 and Hypertrophy
 Liver Neoplasms Antibodies  >28 publications with gp130 and Liver Neoplasms

Organs/Tissues associated with gp130 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >235 publications with gp130 and Blood
 Liver Antibodies  >96 publications with gp130 and Liver
 Bone Antibodies  >90 publications with gp130 and Bone
 Brain Antibodies  >82 publications with gp130 and Brain
 Heart Antibodies  >74 publications with gp130 and Heart
 Bone Marrow Antibodies  >62 publications with gp130 and Bone Marrow
 Lung Antibodies  >37 publications with gp130 and Lung
 Embryonic Tissue Antibodies  >35 publications with gp130 and Embryonic Tissue
 Kidney Antibodies  >20 publications with gp130 and Kidney
 Spleen Antibodies  >19 publications with gp130 and Spleen
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