Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit for Human

Name: Human LNPEP ELISA Kit; Leucyl/Cystinyl Aminopeptidase; MyBioSource
Brand: MyBioSource
SKU: MBS454146
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454146

MBS454146 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit target analytes in biological samples. The concentration gradients of… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Leucyl/Cystinyl Aminopeptidase (LNPEP), ELISA Kit

Full Product Name

Human Leucyl/Cystinyl Aminopeptidase (LNPEP) ELISA Kit

Product Gene Name

LNPEP elisa kit

Product Synonym Names

CAP; PLAP; OTASE; IRAP; Oxytocinase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; Placental leucine aminopeptidase

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates and other biological fluids.

Detection Range

1.56-100ng/mL

Sensitivity

0.58ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

115,062 Da

OMIM

D50810 mRNA

3D Structure

ModBase 3D Structure for Q9UIQ6

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of LNPEP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LNPEP. It may not necessarily be applicable to this product.

NCBI GI #

61742777

NCBI GeneID

4012

NCBI Accession #

NP_005566.2

UniProt Primary Accession #

Q9UIQ6

UniProt Secondary Accession #

O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ7

UniProt Related Accession #

Q9UIQ6

GenBank Nucleotide #

NM_005575.2

NCBI Official Full Name

leucyl-cystinyl aminopeptidase isoform 1

NCBI Official Synonym Full Names

leucyl and cystinyl aminopeptidase

NCBI Official Symbol

LNPEP

NCBI Official Synonym Symbols

CAP; IRAP; PLAP; P-LAP

UniProt Protein Name

Leucyl-cystinyl aminopeptidase

UniProt Synonym Protein Names

Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP

Protein Family

Leucyl-cystinyl aminopeptidase

UniProt Gene Name

LNPEP

UniProt Synonym Gene Names

OTASE; Cystinyl aminopeptidase; IRAP; OTase; P-LAP

NCBI Protein Information

leucyl-cystinyl aminopeptidase

NCBI Summary for LNPEP

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for LNPEP

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Research Articles on LNPEP

1. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LNPEP elisa kit

Reference Product	PubMed Publications
SLC2A4 elisa kit	>2 publications with LNPEP and SLC2A4

Pathways associated with LNPEP elisa kit

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Endosomal/Vacuolar Pathway antibodies	Endosomal/Vacuolar Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Insulin-mediated Glucose Transport Pathway antibodies	Insulin-mediated Glucose Transport Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram
Renin-angiotensin System Pathway antibodies	Renin-angiotensin System Pathway Diagram

Diseases associated with LNPEP elisa kit

Disease Name	Pubmed Publications
Hypertension Antibodies	>2 publications with LNPEP and Hypertension
Brain Diseases Antibodies	>2 publications with LNPEP and Brain Diseases
Inflammation Antibodies	>2 publications with LNPEP and Inflammation
Necrosis Antibodies	>2 publications with LNPEP and Necrosis
Atrophy Antibodies	>1 publications with LNPEP and Atrophy
Fibrosis Antibodies	>1 publications with LNPEP and Fibrosis
Cell Transformation, Neoplastic Antibodies	>1 publications with LNPEP and Cell Transformation, Neoplastic

Organs/Tissues associated with LNPEP elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with LNPEP and Brain
Uterus Antibodies	>1 publications with LNPEP and Uterus