Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit for Mouse

Name: Mouse bACE1 ELISA Kit; Beta-Site APP Cleaving Enzyme 1; MyBioSource
Brand: MyBioSource
SKU: MBS454491
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454491

MBS454491 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit target analytes in biological samples. The concentration gradients of… More details

$485 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Beta-Site APP Cleaving Enzyme 1 (bACE1), ELISA Kit

Full Product Name

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

Product Gene Name

bACE1 elisa kit

Product Synonym Names

ASP2; Beta Secretase; Memapsin 2; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Membrane-associated aspartic protease 2

Species Reactivity

Mouse

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates, cerebrospinal fluid and other biological fluids.

Detection Range

15.625-1000pg/mL

Sensitivity

5.9pg/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

55,748 Da

3D Structure

ModBase 3D Structure for P56818

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of bACE1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for bACE1. It may not necessarily be applicable to this product.

NCBI GI #

225543122

NCBI GeneID

23821

NCBI Accession #

NP_001139419.1

UniProt Primary Accession #

P56818

UniProt Secondary Accession #

Q544D0

UniProt Related Accession #

P56818

GenBank Nucleotide #

NM_001145947.2

NCBI Official Full Name

beta-secretase 1 isoform 2

NCBI Official Synonym Full Names

beta-site APP cleaving enzyme 1

NCBI Official Symbol

Bace1

NCBI Official Synonym Symbols

ASP2; Bace; C76936

UniProt Protein Name

Beta-secretase 1

UniProt Synonym Protein Names

Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2

Protein Family

Beta-secretase

UniProt Gene Name

Bace1

UniProt Synonym Gene Names

Bace; ASP2; Asp 2; Beta-site APP cleaving enzyme 1

NCBI Protein Information

beta-secretase 1

NCBI Summary for bACE1

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

UniProt Comments for bACE1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase ().

Research Articles on bACE1

1. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with bACE1 elisa kit

Reference Product	PubMed Publications
App elisa kit	>1362 publications with bACE1 and App
Psen1 elisa kit	>310 publications with bACE1 and Psen1
Psenen elisa kit	>44 publications with bACE1 and Psenen
Rtn3 elisa kit	>20 publications with bACE1 and Rtn3
Aplp2 elisa kit	>14 publications with bACE1 and Aplp2
Gga1 elisa kit	>14 publications with bACE1 and Gga1
Sorl1 elisa kit	>10 publications with bACE1 and Sorl1
Ncstn elisa kit	>7 publications with bACE1 and Ncstn
Jak2 elisa kit	>3 publications with bACE1 and Jak2

Pathways associated with bACE1 elisa kit

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram

Diseases associated with bACE1 elisa kit

Disease Name	Pubmed Publications
Alzheimer Disease Antibodies	>1508 publications with bACE1 and Alzheimer Disease
Brain Diseases Antibodies	>1409 publications with bACE1 and Brain Diseases
Disease Models, Animal Antibodies	>325 publications with bACE1 and Disease Models, Animal
Memory Disorders Antibodies	>101 publications with bACE1 and Memory Disorders
Inflammation Antibodies	>84 publications with bACE1 and Inflammation
Cognition Disorders Antibodies	>82 publications with bACE1 and Cognition Disorders
Neurobehavioral Manifestations Antibodies	>81 publications with bACE1 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>77 publications with bACE1 and Learning Disorders
Necrosis Antibodies	>73 publications with bACE1 and Necrosis
Nerve Degeneration Antibodies	>30 publications with bACE1 and Nerve Degeneration

Organs/Tissues associated with bACE1 elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1296 publications with bACE1 and Brain
Other Antibodies	>455 publications with bACE1 and Other
Kidney Antibodies	>90 publications with bACE1 and Kidney
Liver Antibodies	>36 publications with bACE1 and Liver
Embryonic Tissue Antibodies	>27 publications with bACE1 and Embryonic Tissue
Ovary Antibodies	>26 publications with bACE1 and Ovary
Eye Antibodies	>23 publications with bACE1 and Eye
Pancreas Antibodies	>18 publications with bACE1 and Pancreas
Spinal Cord Antibodies	>14 publications with bACE1 and Spinal Cord
Skin Antibodies	>13 publications with bACE1 and Skin