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Cluster of Differentiation 40 Ligand (CD40L) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454585

MBS454585 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit target analytes in biological samples. The concentration… More details

$480 / 48 Tests +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cluster Of Differentiation 40 Ligand (CD40L), ELISA Kit
Full Product Name
Human Cluster Of Differentiation 40 Ligand (CD40L) ELISA Kit
Product Gene Name
CD40L elisa kit
Product Synonym Names
CD154; TRAP; HIGM1; IGM; IMD3; TBAM; T-BAM; TNFSF5; Gp39; TNF Superfamily Member 5; Hyper-IgM Syndrome; TNF-Related Activation Protein; T-Cell B-Cell Activating Molecule
Species Reactivity
Human
Assay Type
Sandwich
Samples
Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Detection Range
0.156-10ng/mL
Sensitivity
0.051ng/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
29,274 Da
OMIM
X68550 mRNA
3D Structure
ModBase 3D Structure for P29965
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of CD40L elisa kit

Human CD40L ELISA Kit – Cat# MBS454585

Other Notes

Small volumes of CD40L elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD40L. It may not necessarily be applicable to this product.

NCBI GI #
4557433
NCBI GeneID
959
NCBI Accession #
NP_000065.1
UniProt Primary Accession #
P29965
UniProt Related Accession #
P29965
GenBank Nucleotide #
NM_000074.2
NCBI Official Full Name
CD40 ligand
NCBI Official Synonym Full Names
CD40 ligand
NCBI Official Symbol
CD40LG
NCBI Official Synonym Symbols
IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
UniProt Protein Name
CD40 ligand
UniProt Synonym Protein Names
T-cell antigen Gp39; TNF-related activation protein; TRAP
UniProt Gene Name
CD40LG
UniProt Synonym Gene Names
CD40L; TNFSF5; TRAP; CD40-L; TRAP
NCBI Protein Information
CD40 ligand

NCBI Summary for CD40L

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for CD40L

Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching ().
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Research Articles on CD40L

1. It is likely that the CD40/CD40L interactions and TNF alpha are effective against cervical carcinomas by repressing transcriptional activity of human papilloma virus-18 promoter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD40L elisa kit

 Reference Product  PubMed Publications
 CD40 elisa kit  >42 publications with CD40L and CD40
 IL2 elisa kit  >2 publications with CD40L and IL2
 TRAF1 elisa kit  >2 publications with CD40L and TRAF1
 ITGAM elisa kit  >1 publications with CD40L and ITGAM
 CD27 elisa kit  >1 publications with CD40L and CD27
 TRAF2 elisa kit  >1 publications with CD40L and TRAF2
 BIRC3 elisa kit  >1 publications with CD40L and BIRC3

Pathways associated with CD40L elisa kit

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram

Diseases associated with CD40L elisa kit

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >15 publications with CD40L and Autoimmune Diseases
 Inflammation Antibodies  >14 publications with CD40L and Inflammation
 Necrosis Antibodies  >10 publications with CD40L and Necrosis
 Cardiovascular Diseases Antibodies  >8 publications with CD40L and Cardiovascular Diseases
 Hyper-IgM Immunodeficiency Syndrome, Type 1 Antibodies  >6 publications with CD40L and Hyper-IgM Immunodeficiency Syndrome, Type 1
 Heart Diseases Antibodies  >5 publications with CD40L and Heart Diseases
 Anemia Antibodies  >4 publications with CD40L and Anemia
 Pneumonia Antibodies  >4 publications with CD40L and Pneumonia
 Myocardial Infarction Antibodies  >3 publications with CD40L and Myocardial Infarction
 Hypersensitivity Antibodies  >3 publications with CD40L and Hypersensitivity

Organs/Tissues associated with CD40L elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with CD40L and Blood
 Mixed Antibodies  >2 publications with CD40L and Mixed
 Thymus Antibodies  >1 publications with CD40L and Thymus
 Brain Antibodies  >1 publications with CD40L and Brain
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