Membrane Cofactor (MCP) ELISA Kit for Human

Name: Human MCP ELISA Kit; Membrane Cofactor; MyBioSource
Brand: MyBioSource
SKU: MBS454705
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454705

MBS454705 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Membrane Cofactor Protein (MCP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Membrane Cofactor Protein (MCP), ELISA Kit

Full Product Name

Human Membrane Cofactor Protein (MCP) ELISA Kit

Product Gene Name

MCP elisa kit

Product Synonym Names

CD46; MIC10; TLX; TRA2; Trophoblast leukocyte common antigen; CD46 Molecule,Complement Regulatory Protein; CD46 Molecule,Complement Regulatory protein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, urine, saliva and other biological fluids.

Detection Range

6.25-400pg/mL

Sensitivity

2.34pg/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

36,826 Da

OMIM

Y00651 mRNA

3D Structure

ModBase 3D Structure for P15529

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of MCP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MCP. It may not necessarily be applicable to this product.

NCBI GI #

27502402

NCBI GeneID

4179

NCBI Accession #

NP_002380.3

UniProt Primary Accession #

P15529

UniProt Secondary Accession #

Q15429; Q53GV9; Q5HY94; Q5VWS6; Q5VWS7; Q5VWS8; Q5VWS9; Q5VWT0; A0T1T0; A0T1T1; A0T1T2

UniProt Related Accession #

P15529

GenBank Nucleotide #

NM_002389.4

NCBI Official Full Name

membrane cofactor protein isoform 1

NCBI Official Synonym Full Names

CD46 molecule

NCBI Official Symbol

CD46

NCBI Official Synonym Symbols

MCP; TLX; AHUS2; MIC10; TRA2.10

UniProt Protein Name

Membrane cofactor protein

UniProt Synonym Protein Names

TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46

UniProt Gene Name

CD46

UniProt Synonym Gene Names

MCP; MIC10

NCBI Protein Information

membrane cofactor protein

NCBI Summary for MCP

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

UniProt Comments for MCP

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

Research Articles on MCP

1. This study suggests that the promoter polymorphism (rs2796267, -496 A/G) CD46 gene may be related to susceptibility of acute renal allograft rejection in Korean kidney transplantation recipients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MCP elisa kit

Reference Product	PubMed Publications
CD59 elisa kit	>338 publications with MCP and CD59
CR1 elisa kit	>75 publications with MCP and CR1
SLAMF1 elisa kit	>39 publications with MCP and SLAMF1
CFI elisa kit	>39 publications with MCP and CFI
C4A elisa kit	>4 publications with MCP and C4A

Pathways associated with MCP elisa kit

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with MCP elisa kit

Disease Name	Pubmed Publications
Measles Antibodies	>382 publications with MCP and Measles
Kidney Diseases Antibodies	>137 publications with MCP and Kidney Diseases
Anemia Antibodies	>113 publications with MCP and Anemia
Inflammation Antibodies	>111 publications with MCP and Inflammation
Atypical Hemolytic Uremic Syndrome Antibodies	>95 publications with MCP and Atypical Hemolytic Uremic Syndrome
Necrosis Antibodies	>65 publications with MCP and Necrosis
Brain Diseases Antibodies	>56 publications with MCP and Brain Diseases
Lung Diseases Antibodies	>39 publications with MCP and Lung Diseases
Liver Diseases Antibodies	>32 publications with MCP and Liver Diseases
Breast Neoplasms Antibodies	>27 publications with MCP and Breast Neoplasms

Organs/Tissues associated with MCP elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>562 publications with MCP and Blood
Kidney Antibodies	>127 publications with MCP and Kidney
Vascular Antibodies	>106 publications with MCP and Vascular
Brain Antibodies	>99 publications with MCP and Brain
Liver Antibodies	>79 publications with MCP and Liver
Lung Antibodies	>78 publications with MCP and Lung
Heart Antibodies	>68 publications with MCP and Heart
Bone Antibodies	>52 publications with MCP and Bone
Skin Antibodies	>44 publications with MCP and Skin
Muscle Antibodies	>39 publications with MCP and Muscle