Phospholipase A2, Calcium Independent (iPLA2) ELISA Kit for Human

Name: Human iPLA2 ELISA Kit; Phospholipase A2, Calcium Independent; MyBioSource
Brand: MyBioSource
SKU: MBS454885
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS454885

MBS454885 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Phospholipase A2, Calcium Independent (iPLA2) ELISA Kit target analytes in biological samples. The concentration… More details

$480 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Phospholipase A2, Calcium Independent (iPLA2), ELISA Kit

Full Product Name

Human Phospholipase A2, Calcium Independent (iPLA2) ELISA Kit

Product Gene Name

iPLA2 elisa kit

Product Synonym Names

PLA2G6; CaI-PLA2; GVI; INAD1; PNPLA9; Ca2+ Independent PLA2; 85 kDa Calcium-Independent Phospholipase A2; Phospholipase A2,group VI(Cytosolic,Calcium-Independent)

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma and other biological fluids.

Detection Range

78.125-5000pg/mL

Sensitivity

32pg/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

46,484 Da

OMIM

AF064594 mRNA

3D Structure

ModBase 3D Structure for O60733

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of iPLA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for iPLA2. It may not necessarily be applicable to this product.

NCBI GI #

52486251

NCBI GeneID

8398

NCBI Accession #

NP_001004426.1

UniProt Primary Accession #

O60733

UniProt Secondary Accession #

O75645; Q8N452; Q9UG29; Q9UIT0; Q9Y671; A8K597; B0QYE8

UniProt Related Accession #

O60733

GenBank Nucleotide #

NM_001004426.1

NCBI Official Full Name

85/88 kDa calcium-independent phospholipase A2 isoform b

NCBI Official Synonym Full Names

phospholipase A2 group VI

NCBI Official Symbol

PLA2G6

NCBI Official Synonym Symbols

GVI; PLA2; INAD1; NBIA2; iPLA2; NBIA2A; NBIA2B; PARK14; PNPLA9; CaI-PLA2; IPLA2-VIA; iPLA2beta

UniProt Protein Name

85/88 kDa calcium-independent phospholipase A2

UniProt Synonym Protein Names

Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Patatin-like phospholipase domain-containing protein 9; PNPLA9

UniProt Gene Name

PLA2G6

UniProt Synonym Gene Names

PLPLA9; CaI-PLA2; GVI PLA2; iPLA2-beta; PNPLA9

NCBI Protein Information

85/88 kDa calcium-independent phospholipase A2

NCBI Summary for iPLA2

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

UniProt Comments for iPLA2

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.

Research Articles on iPLA2

1. A homozygous novel mutation at position c.2277-1G>C in PLA2G6 gene presumed to give rise to altered splicing, was detected, thus confirming the diagnosis of infantile Neuroaxonal Dystrophy (INAD).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with iPLA2 elisa kit

Reference Product	PubMed Publications
PLA2G4A elisa kit	>124 publications with iPLA2 and PLA2G4A
PTGS2 elisa kit	>15 publications with iPLA2 and PTGS2
PLA2G2A elisa kit	>6 publications with iPLA2 and PLA2G2A
PLA2G7 elisa kit	>4 publications with iPLA2 and PLA2G7
PLA2G15 elisa kit	>2 publications with iPLA2 and PLA2G15

Pathways associated with iPLA2 elisa kit

Products by Pathway	Pathway Diagram
Acyl Chain Remodeling Of CL Pathway antibodies	Acyl Chain Remodeling Of CL Pathway Diagram
Acyl Chain Remodelling Of PC Pathway antibodies	Acyl Chain Remodelling Of PC Pathway Diagram
Acyl Chain Remodelling Of PE Pathway antibodies	Acyl Chain Remodelling Of PE Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
COPI-independent Golgi-to-ER Retrograde Traffic Pathway antibodies	COPI-independent Golgi-to-ER Retrograde Traffic Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram

Diseases associated with iPLA2 elisa kit

Disease Name	Pubmed Publications
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A Antibodies	>53 publications with iPLA2 and NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A
Death Antibodies	>47 publications with iPLA2 and Death
Inflammation Antibodies	>36 publications with iPLA2 and Inflammation
Atrophy Antibodies	>33 publications with iPLA2 and Atrophy
Cardiovascular Diseases Antibodies	>28 publications with iPLA2 and Cardiovascular Diseases
Neurologic Manifestations Antibodies	>20 publications with iPLA2 and Neurologic Manifestations
Diabetes Mellitus Antibodies	>15 publications with iPLA2 and Diabetes Mellitus
Heart Diseases Antibodies	>11 publications with iPLA2 and Heart Diseases
Atherosclerosis Antibodies	>10 publications with iPLA2 and Atherosclerosis
Necrosis Antibodies	>9 publications with iPLA2 and Necrosis

Organs/Tissues associated with iPLA2 elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>143 publications with iPLA2 and Brain
Blood Antibodies	>62 publications with iPLA2 and Blood
Pancreas Antibodies	>26 publications with iPLA2 and Pancreas
Nerve Antibodies	>20 publications with iPLA2 and Nerve
Lung Antibodies	>19 publications with iPLA2 and Lung
Eye Antibodies	>18 publications with iPLA2 and Eye
Skin Antibodies	>16 publications with iPLA2 and Skin
Liver Antibodies	>15 publications with iPLA2 and Liver
Kidney Antibodies	>15 publications with iPLA2 and Kidney
Bone Antibodies	>10 publications with iPLA2 and Bone