Filamin A Alpha (FLNa) ELISA Kit for Human

Name: Human FLNa ELISA Kit; Filamin A Alpha; MyBioSource
Brand: MyBioSource
SKU: MBS455122
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS455122

MBS455122 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin A Alpha (FLNa) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Filamin A Alpha (FLNa), ELISA Kit

Full Product Name

Human Filamin A Alpha (FLNa) ELISA Kit

Product Gene Name

FLNa elisa kit

Product Synonym Names

ABP280 FLN-A ABPX FLN FLN1 FMD MNS NHBP OPD OPD1 OPD2 Actin Binding Protein 280 Endothelial actin-binding protein Filamin-1 Non-muscle filamin

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Detection Range

1.875-120ng/mL

Sensitivity

0.72ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

280,018 Da

OMIM

X53416 mRNA

3D Structure

ModBase 3D Structure for P21333

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of FLNa elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FLNa. It may not necessarily be applicable to this product.

NCBI GI #

160420317

NCBI GeneID

2316

NCBI Accession #

NP_001104026.1

UniProt Primary Accession #

P21333

UniProt Secondary Accession #

Q5HY53; Q5HY55; Q8NF52; E9KL45

UniProt Related Accession #

P21333

GenBank Nucleotide #

NM_001110556.1

NCBI Official Full Name

filamin-A isoform 2

NCBI Official Synonym Full Names

filamin A

NCBI Official Symbol

FLNA

NCBI Official Synonym Symbols

FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280

UniProt Protein Name

Filamin-A

UniProt Synonym Protein Names

Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin

Protein Family

Filamin

UniProt Gene Name

FLNA

UniProt Synonym Gene Names

FLN; FLN1; FLN-A; ABP-280

NCBI Protein Information

filamin-A

NCBI Summary for FLNa

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

UniProt Comments for FLNa

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintainance ().

Research Articles on FLNa

1. Results indicate that mTORC2 regulates filamin A-dependent focal adhesions and cell migration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FLNa elisa kit

Reference Product	PubMed Publications
ARHGAP24 elisa kit	>7 publications with FLNa and ARHGAP24
CDC42 elisa kit	>6 publications with FLNa and CDC42
PAK1 elisa kit	>5 publications with FLNa and PAK1
CAV1 elisa kit	>3 publications with FLNa and CAV1
FBLIM1 elisa kit	>3 publications with FLNa and FBLIM1
FILIP1 elisa kit	>1 publications with FLNa and FILIP1
RALA elisa kit	>1 publications with FLNa and RALA

Pathways associated with FLNa elisa kit

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-extracellular Matrix Interactions Pathway antibodies	Cell-extracellular Matrix Interactions Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
GP1b-IX-V Activation Signalling Pathway antibodies	GP1b-IX-V Activation Signalling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Hypothesized Pathways In Pathogenesis Of Cardiovascular Disease antibodies	Hypothesized Pathways In Pathogenesis Of Cardiovascular Disease Diagram

Diseases associated with FLNa elisa kit

Disease Name	Pubmed Publications
Periventricular Nodular Heterotopia Antibodies	>77 publications with FLNa and Periventricular Nodular Heterotopia
Epilepsy Antibodies	>40 publications with FLNa and Epilepsy
Frontometaphyseal dysplasia Antibodies	>18 publications with FLNa and Frontometaphyseal dysplasia
Heart Diseases Antibodies	>16 publications with FLNa and Heart Diseases
Osteochondrodysplasias Antibodies	>14 publications with FLNa and Osteochondrodysplasias
Neoplasm Metastasis Antibodies	>10 publications with FLNa and Neoplasm Metastasis
TERMINAL OSSEOUS DYSPLASIA Antibodies	>7 publications with FLNa and TERMINAL OSSEOUS DYSPLASIA
Fibrosis Antibodies	>7 publications with FLNa and Fibrosis
Breast Neoplasms Antibodies	>6 publications with FLNa and Breast Neoplasms
Inflammation Antibodies	>5 publications with FLNa and Inflammation

Organs/Tissues associated with FLNa elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>88 publications with FLNa and Brain
Blood Antibodies	>43 publications with FLNa and Blood
Vascular Antibodies	>31 publications with FLNa and Vascular
Heart Antibodies	>30 publications with FLNa and Heart
Bone Antibodies	>29 publications with FLNa and Bone
Muscle Antibodies	>25 publications with FLNa and Muscle
Lung Antibodies	>17 publications with FLNa and Lung
Skin Antibodies	>16 publications with FLNa and Skin
Connective Tissue Antibodies	>16 publications with FLNa and Connective Tissue
Prostate Antibodies	>15 publications with FLNa and Prostate