Melanoma Associated ME20 (ME20M) ELISA Kit for Human

Name: Human ME20M ELISA Kit; Melanoma Associated ME20; MyBioSource
Brand: MyBioSource
SKU: MBS455192
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS455192

MBS455192 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Melanoma Associated ME20 (ME20M) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Melanoma Associated ME20 (ME20M), ELISA Kit

Full Product Name

Human Melanoma Associated ME20 (ME20M) ELISA Kit

Product Gene Name

ME20M elisa kit

Product Synonym Names

PMEL; GP100; SI; SIL; SILV; Pmel17; Silver Homolog; Premelanosome Protein; Silver Locus Protein Homolog; 95 kDa melanocyte-specific secreted glycoprotein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.156-10ng/mL

Sensitivity

0.061ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

66,729 Da

OMIM

M77348 mRNA

3D Structure

ModBase 3D Structure for P40967

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of ME20M elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ME20M. It may not necessarily be applicable to this product.

NCBI GI #

318037593

NCBI GeneID

6490

NCBI Accession #

NP_001186982.1

UniProt Primary Accession #

P40967

UniProt Secondary Accession #

Q12763; Q14448; Q14817; Q16565; B3KS57; B7Z6D7

UniProt Related Accession #

P40967

GenBank Nucleotide #

NM_001200053.1

NCBI Official Full Name

melanocyte protein PMEL isoform 2

NCBI Official Synonym Full Names

premelanosome protein

NCBI Official Symbol

PMEL

NCBI Official Synonym Symbols

P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

UniProt Protein Name

Melanocyte protein PMEL

UniProt Synonym Protein Names

ME20-M; ME20M

UniProt Gene Name

PMEL

UniProt Synonym Gene Names

D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S

NCBI Protein Information

melanocyte protein PMEL

NCBI Summary for ME20M

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

UniProt Comments for ME20M

Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

Research Articles on ME20M

1. our work attempts to provide structural insights into the RPT domain structure and to elucidate its contribution to Pmel17 amyloid fibril formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ME20M elisa kit

Reference Product	PubMed Publications
MLANA elisa kit	>131 publications with ME20M and MLANA
TYRP1 elisa kit	>39 publications with ME20M and TYRP1
MITF elisa kit	>33 publications with ME20M and MITF
MAGEA3 elisa kit	>25 publications with ME20M and MAGEA3
TYR elisa kit	>17 publications with ME20M and TYR

Diseases associated with ME20M elisa kit

Disease Name	Pubmed Publications
Melanoma Antibodies	>529 publications with ME20M and Melanoma
Skin Diseases Antibodies	>119 publications with ME20M and Skin Diseases
Neoplasms, Experimental Antibodies	>97 publications with ME20M and Neoplasms, Experimental
Disease Models, Animal Antibodies	>90 publications with ME20M and Disease Models, Animal
Lung Neoplasms Antibodies	>19 publications with ME20M and Lung Neoplasms
Lung Diseases Antibodies	>17 publications with ME20M and Lung Diseases
Necrosis Antibodies	>17 publications with ME20M and Necrosis
Inflammation Antibodies	>8 publications with ME20M and Inflammation
Liver Neoplasms Antibodies	>8 publications with ME20M and Liver Neoplasms
Adenocarcinoma Antibodies	>6 publications with ME20M and Adenocarcinoma

Organs/Tissues associated with ME20M elisa kit

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>136 publications with ME20M and Skin
Lung Antibodies	>25 publications with ME20M and Lung
Eye Antibodies	>24 publications with ME20M and Eye
Spleen Antibodies	>19 publications with ME20M and Spleen
Brain Antibodies	>16 publications with ME20M and Brain
Kidney Antibodies	>12 publications with ME20M and Kidney
Liver Antibodies	>10 publications with ME20M and Liver
Bone Antibodies	>10 publications with ME20M and Bone
Muscle Antibodies	>9 publications with ME20M and Muscle
Testis Antibodies	>8 publications with ME20M and Testis