Cyclin Dependent Kinase 4 (CDK4) ELISA Kit for Human

Name: Human CDK4 ELISA Kit; Cyclin Dependent Kinase 4; MyBioSource
Brand: MyBioSource
SKU: MBS455228
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS455228

MBS455228 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cyclin Dependent Kinase 4 (CDK4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Cyclin Dependent Kinase 4 (CDK4), ELISA Kit

Full Product Name

Human Cyclin Dependent Kinase 4 (CDK4) ELISA Kit

Product Gene Name

CDK4 elisa kit

Product Synonym Names

AIS; DHTR; HUMARA; KD; NR3C4; NR3-C4; SBMA; SMAX1; TFM;

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.121ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

20,725 Da

OMIM

M14505 mRNA

3D Structure

ModBase 3D Structure for P11802

Intra Assay

CV<10%

Inter Assay

CV<12%

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of CDK4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK4. It may not necessarily be applicable to this product.

NCBI GI #

4502735

NCBI GeneID

1019

NCBI Accession #

NP_000066.1

UniProt Primary Accession #

P11802

UniProt Secondary Accession #

O00576; Q6FG61; B2R9A0; B4DNF9

UniProt Related Accession #

P11802

GenBank Nucleotide #

NM_000075.3

NCBI Official Full Name

cyclin-dependent kinase 4

NCBI Official Synonym Full Names

cyclin dependent kinase 4

NCBI Official Symbol

CDK4

NCBI Official Synonym Symbols

CMM3; PSK-J3

UniProt Protein Name

Cyclin-dependent kinase 4

UniProt Synonym Protein Names

Cell division protein kinase 4; PSK-J3

Protein Family

Cyclin-dependent kinase

UniProt Gene Name

CDK4

NCBI Protein Information

cyclin-dependent kinase 4

NCBI Summary for CDK4

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for CDK4

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Research Articles on CDK4

1. both miR-613 mimics and inhibitors could decrease and increase CDK4 protein levels in non-small cell lung cancer-derived cells, respectively.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDK4 elisa kit

Reference Product	PubMed Publications
CDKN1A elisa kit	>831 publications with CDK4 and CDKN1A
CDKN2A elisa kit	>715 publications with CDK4 and CDKN2A
CDKN1B elisa kit	>711 publications with CDK4 and CDKN1B
CCND1 elisa kit	>295 publications with CDK4 and CCND1
CCND3 elisa kit	>163 publications with CDK4 and CCND3
CCND2 elisa kit	>159 publications with CDK4 and CCND2
CDKN2B elisa kit	>128 publications with CDK4 and CDKN2B
RB1 elisa kit	>113 publications with CDK4 and RB1
CDKN2C elisa kit	>103 publications with CDK4 and CDKN2C
CDC37 elisa kit	>33 publications with CDK4 and CDC37

Pathways associated with CDK4 elisa kit

Products by Pathway	Pathway Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Breast Cancer Pathway antibodies	Breast Cancer Pathway Diagram
Breast Cancer Pathway antibodies	Breast Cancer Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram

Diseases associated with CDK4 elisa kit

Disease Name	Pubmed Publications
Carcinoma Antibodies	>942 publications with CDK4 and Carcinoma
Breast Neoplasms Antibodies	>396 publications with CDK4 and Breast Neoplasms
Adenocarcinoma Antibodies	>377 publications with CDK4 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>251 publications with CDK4 and Cell Transformation, Neoplastic
Skin Neoplasms Antibodies	>233 publications with CDK4 and Skin Neoplasms
Neoplasms, Experimental Antibodies	>219 publications with CDK4 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>213 publications with CDK4 and Lung Neoplasms
Liver Diseases Antibodies	>194 publications with CDK4 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>183 publications with CDK4 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>181 publications with CDK4 and Liver Neoplasms

Organs/Tissues associated with CDK4 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>470 publications with CDK4 and Blood
Lung Antibodies	>364 publications with CDK4 and Lung
Liver Antibodies	>322 publications with CDK4 and Liver
Skin Antibodies	>315 publications with CDK4 and Skin
Muscle Antibodies	>315 publications with CDK4 and Muscle
Brain Antibodies	>306 publications with CDK4 and Brain
Vascular Antibodies	>260 publications with CDK4 and Vascular
Bone Antibodies	>211 publications with CDK4 and Bone
Prostate Antibodies	>182 publications with CDK4 and Prostate
Kidney Antibodies	>125 publications with CDK4 and Kidney