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Histone Deacetylase 4 (HDAC4) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS455241

MBS455241 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Histone Deacetylase 4 (HDAC4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Histone Deacetylase 4 (HDAC4), ELISA Kit
Full Product Name
Human Histone Deacetylase 4 (HDAC4) ELISA Kit
Product Gene Name
HDAC4 elisa kit
Product Synonym Names
HD4 HDAC-A HDACA
Species Reactivity
Human
Assay Type
Sandwich
Samples
Tissue homogenates and other biological fluids.
Detection Range
1.56-100ng/mL
Sensitivity
0.55ng/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
106,367 Da
OMIM
AF132607 mRNA
3D Structure
ModBase 3D Structure for P56524
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of HDAC4 elisa kit

Human HDAC4 ELISA Kit – Cat# MBS455241

Other Notes

Small volumes of HDAC4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC4. It may not necessarily be applicable to this product.

NCBI GI #
153085395
NCBI GeneID
9759
NCBI Accession #
NP_006028.2
UniProt Primary Accession #
P56524
UniProt Secondary Accession #
Q86YH7; Q9UND6; E9PGB9; F5GX36
UniProt Related Accession #
P56524
GenBank Nucleotide #
NM_006037.3
NCBI Official Full Name
histone deacetylase 4
NCBI Official Synonym Full Names
histone deacetylase 4
NCBI Official Symbol
HDAC4
NCBI Official Synonym Symbols
HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
UniProt Protein Name
Histone deacetylase 4
UniProt Gene Name
HDAC4
UniProt Synonym Gene Names
KIAA0288; HD4
NCBI Protein Information
histone deacetylase 4

NCBI Summary for HDAC4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
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UniProt Comments for HDAC4

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
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Research Articles on HDAC4

1. HDAC4 increases endogenous SIRT1 expression by enhancing its sumoylation modification levels

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HDAC4 elisa kit

 Products by Pathway  Pathway Diagram
 ATM Signaling Network In Development And Disease Pathway antibodies  ATM Signaling Network In Development And Disease Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Cardiac Hypertrophic Response Pathway antibodies  Cardiac Hypertrophic Response Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram

Diseases associated with HDAC4 elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >74 publications with HDAC4 and Nervous System Diseases
 Carcinoma Antibodies  >46 publications with HDAC4 and Carcinoma
 Heart Diseases Antibodies  >36 publications with HDAC4 and Heart Diseases
 Inflammation Antibodies  >35 publications with HDAC4 and Inflammation
 Vascular Diseases Antibodies  >33 publications with HDAC4 and Vascular Diseases
 Adenocarcinoma Antibodies  >19 publications with HDAC4 and Adenocarcinoma
 Intellectual Disability Antibodies  >18 publications with HDAC4 and Intellectual Disability
 Fibrosis Antibodies  >17 publications with HDAC4 and Fibrosis
 Lung Neoplasms Antibodies  >17 publications with HDAC4 and Lung Neoplasms
 Brachydactyly Antibodies  >16 publications with HDAC4 and Brachydactyly

Organs/Tissues associated with HDAC4 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >164 publications with HDAC4 and Muscle
 Brain Antibodies  >94 publications with HDAC4 and Brain
 Heart Antibodies  >67 publications with HDAC4 and Heart
 Bone Antibodies  >61 publications with HDAC4 and Bone
 Blood Antibodies  >56 publications with HDAC4 and Blood
 Lung Antibodies  >35 publications with HDAC4 and Lung
 Liver Antibodies  >31 publications with HDAC4 and Liver
 Embryonic Tissue Antibodies  >24 publications with HDAC4 and Embryonic Tissue
 Prostate Antibodies  >18 publications with HDAC4 and Prostate
 Thyroid Antibodies  >17 publications with HDAC4 and Thyroid
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