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Protectin (CD59) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS455738

MBS455738 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protectin (CD59) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protectin (CD59), ELISA Kit
Full Product Name
Human Protectin (CD59) ELISA Kit
Product Gene Name
CD59 elisa kit
Product Synonym Names
MIC11; MIN1; MIN2; MIN3; MSK21; MAC-IP; MACIF; MIRL; HRF20; Complement Regulatory Protein; 20 kDa homologous restriction factor; Membrane attack complex inhibition factor
Species Reactivity
Human
Assay Type
Sandwich
Samples
Serum, plasma, cell lysates and other biological fluids.
Detection Range
31.25-2000pg/mL
Sensitivity
13.7pg/mL
Preparation and Storage
For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.
Molecular Weight
14,177 Da
OMIM
M27909 mRNA
3D Structure
ModBase 3D Structure for P13987
Intra Assay
CV<10%
Inter Assay
CV<12%
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of CD59 elisa kit

Human CD59 ELISA Kit – Cat# MBS455738

Other Notes

Small volumes of CD59 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.

NCBI GI #
10835165
NCBI GeneID
966
NCBI Accession #
NP_000602.1
UniProt Primary Accession #
P13987
UniProt Related Accession #
P13987
GenBank Nucleotide #
NM_000611.5
NCBI Official Full Name
CD59 glycoprotein preproprotein
NCBI Official Synonym Full Names
CD59 molecule
NCBI Official Symbol
CD59
NCBI Official Synonym Symbols
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
UniProt Protein Name
CD59 glycoprotein
UniProt Synonym Protein Names
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
Protein Family
CD59 glycoprotein
UniProt Gene Name
CD59
UniProt Synonym Gene Names
MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL
NCBI Protein Information
CD59 glycoprotein

NCBI Summary for CD59

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD59

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
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Research Articles on CD59

1. Study revealed that CD59 is overexpressed in breast cancer tumors and correlates with poor survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD59 elisa kit

 Reference Product  PubMed Publications
 CD55 elisa kit  >883 publications with CD59 and CD55
 CD46 elisa kit  >338 publications with CD59 and CD46
 CD2 elisa kit  >40 publications with CD59 and CD2
 C8A elisa kit  >1 publications with CD59 and C8A

Pathways associated with CD59 elisa kit

 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with CD59 elisa kit

 Disease Name  Pubmed Publications
 Anemia Antibodies  >442 publications with CD59 and Anemia
 Inflammation Antibodies  >175 publications with CD59 and Inflammation
 Necrosis Antibodies  >88 publications with CD59 and Necrosis
 Kidney Diseases Antibodies  >65 publications with CD59 and Kidney Diseases
 Brain Diseases Antibodies  >41 publications with CD59 and Brain Diseases
 Adenocarcinoma Antibodies  >40 publications with CD59 and Adenocarcinoma
 Lung Diseases Antibodies  >38 publications with CD59 and Lung Diseases
 CD59 Deficiency Antibodies  >36 publications with CD59 and CD59 Deficiency
 Proteinuria Antibodies  >34 publications with CD59 and Proteinuria
 Breast Neoplasms Antibodies  >29 publications with CD59 and Breast Neoplasms

Organs/Tissues associated with CD59 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1027 publications with CD59 and Blood
 Vascular Antibodies  >218 publications with CD59 and Vascular
 Bone Antibodies  >206 publications with CD59 and Bone
 Bone Marrow Antibodies  >197 publications with CD59 and Bone Marrow
 Kidney Antibodies  >132 publications with CD59 and Kidney
 Heart Antibodies  >95 publications with CD59 and Heart
 Muscle Antibodies  >84 publications with CD59 and Muscle
 Liver Antibodies  >83 publications with CD59 and Liver
 Lung Antibodies  >76 publications with CD59 and Lung
 Brain Antibodies  >69 publications with CD59 and Brain
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